{"created":"2023-07-27T06:50:44.091341+00:00","id":43765,"links":{},"metadata":{"_buckets":{"deposit":"0195eea5-0d6e-4ac0-81ba-d26a421309ab"},"_deposit":{"created_by":18,"id":"43765","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43765"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043765","sets":["2812:2813:2820"]},"author_link":["71973","71972"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-06-04","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2011-04-01 – 2014-03-31","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"増殖因子による幹細胞ならびに癌幹細胞の制御を調べるために、その細胞内シグナル伝達を担うFRS2ファミリー分子、FRS2alphaとFRS2betaのノックアウトマウスならびに変異マウスを作出し、解析を行った。その結果、FRS2alphaは、主にFGFシグナルの欠損により、視神経の網膜への投射、内耳の形成ならびに神経の痛み刺激に関わる神経の発達に重要であることがわかった。一方、FRS2betaは、乳癌幹細胞の維持に重要であった。","subitem_description_type":"Abstract"},{"subitem_description":"In order to examine the molecular mechanisms how growth factor signaling play roles for maintenance of tissue specific stem cells and cancer stem cells, we made mutant mice of FRS2alpha or FRS2beta, mediators for intracellular signaling through FGF or EGF, respectively. We found that FRS2alpha plays important roles for axon path finding of optic nerves, development of inner ears and sensory neurons. On the other hand, FRS2beta plays important roles for maintenance of breast cancer stem cells.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23390062, 研究期間(年度):2011-04-01 – 2014-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「増殖因子による幹細胞制御のシステム統合解析による分子機構の解明」課題番号:23390062\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23390062/23390062seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050107","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学がん進展制御研究所 / 東京大学"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10251448"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10251448","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390062/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390062/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23390062/23390062seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23390062/23390062seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-15"}],"displaytype":"detail","filename":"CA-PR-GOTOH-N-kaken 2014-4p.pdf","filesize":[{"value":"294.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-GOTOH-N-kaken 2014-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43765/files/CA-PR-GOTOH-N-kaken 2014-4p.pdf"},"version_id":"421a2c4f-87d8-4d4b-9d9f-eb1fc9ffbafe"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"増殖因子による幹細胞制御のシステム統合解析による分子機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"増殖因子による幹細胞制御のシステム統合解析による分子機構の解明"},{"subitem_title":"Systems analysis of molecular mechanisms of growth factor regulation of stem cells","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-15"},"publish_date":"2018-02-15","publish_status":"0","recid":"43765","relation_version_is_last":true,"title":["増殖因子による幹細胞制御のシステム統合解析による分子機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:22:06.881980+00:00"}