{"created":"2023-07-27T06:50:44.136502+00:00","id":43766,"links":{},"metadata":{"_buckets":{"deposit":"b288dc57-aa78-491b-9975-94ded4d27a64"},"_deposit":{"created_by":18,"id":"43766","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43766"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043766","sets":["2812:2813:2819"]},"author_link":["71972","71976"],"item_9_alternative_title_2":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"癌幹細胞を標的とする腫瘍根絶技術の新構築"},{"subitem_alternative_title":"Development of Novel Treatment Strategies Targeting Cancer Stem Cells"}]},"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-29","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2010-04-01 – 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 新学術領域研究(研究領域提案型) 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"乳癌幹細胞スフェア培養の系で、HER2-NFkBパスウエイもしくはHER2-PI3Kパスウエイを阻害し、詳細な時系列をとってRNAを抽出し、DNAマイクロアレイ解析を行った。得られた分子IGF2, AR, GDF15などが癌幹細胞維持に重要な役割を果たしていることを、乳癌臨床検体を用いて確かめた。HER2/ErbB2乳癌自然発症モデルMMTV-ErbB2マウスとFRS2betaノックアウトマウスを交配させたマウスを用いて解析を行い、FRS2betaによってErbBシグナルを効果的に減弱させることにより、癌幹細胞の自己複製能が維持させる仕組みを明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"In order to analyze HER2/ErbB2-PI3K-NFkB pathway in breast cancer stem cells, DNA microarray analysis was performed by using breast cancer cells stimulated with HER2 in the presence or absence of NFkB inhibitor or PI3K inhibitor. We identified several candidate molecular targets in breast cancer stem cells, IGF2, AR, GDF15, for example. We confirmed that these molecules play important roles for stemness of breast cancer cells.\nWe analyzed FRS2beta knockout mice in the background of MMTV-ErbB2 mammary tumor model. We found that FRS2beta play important roles for stemness of mammary tumors through fine-tuning of ErbB2 signaling.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22130009, 研究期間(年度):2010-04-01 – 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「システム生物学的手法を用いた癌幹細胞の新規分子標的の同定」課題番号22130009\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-22130009/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所 / 東京大学","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050108","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10251448"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10251448","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-22130009/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-22130009/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PLANNED-22130009/22130009seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PLANNED-22130009/22130009seika/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-AREA-3221/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-AREA-3221/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/en/grant/KAKENHI-AREA-3221/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/en/grant/KAKENHI-AREA-3221/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-15"}],"displaytype":"detail","filename":"CA-PR-GOTOH-N-kaken 2015-6p.pdf","filesize":[{"value":"357.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-GOTOH-N-kaken 2015-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43766/files/CA-PR-GOTOH-N-kaken 2015-6p.pdf"},"version_id":"040a9f2c-1dd6-4f9c-929c-d408e6c75d0e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"システム生物学的手法を用いた癌幹細胞の新規分子標的の同定","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"システム生物学的手法を用いた癌幹細胞の新規分子標的の同定"},{"subitem_title":"Analyses of novel molecular targets of cancer stem cells by systems analysis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-15"},"publish_date":"2018-02-15","publish_status":"0","recid":"43766","relation_version_is_last":true,"title":["システム生物学的手法を用いた癌幹細胞の新規分子標的の同定"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:44:54.296269+00:00"}