{"created":"2023-07-27T06:50:44.314694+00:00","id":43770,"links":{},"metadata":{"_buckets":{"deposit":"31d3ac58-c304-4381-b55d-7497e2e7d6ae"},"_deposit":{"created_by":18,"id":"43770","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43770"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043770","sets":["2812:2813:2822"]},"author_link":["71981","71982"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-04-27","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2008-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"PYNOD(NLRP10)は、我々が発見した新規の細胞内分子であるが、現在までのところ、個体レベルでの機能は全く不明である。我々はPYNODの生理的機能に迫るためPYNOD欠損マウスの樹立に成功した。PYNOD欠損マウスから調整したケラチノサイトではUVB刺激によるTNF.の産生が低下していた。さらにUVB照射後の表皮におけるTNF.の産生についてもPYNOD欠損マウスで減弱していた。またUVB照射後の血清中のIFN.の値がPYNOD欠損マウスで高値を示すことを発見した。以上の結果から、PYNODは皮膚においてUVB刺激後におこるTNF.の産生に関して重要な分子であることが明らかとなり、局所でおこる炎症反応において重要な分子と考えられる。","subitem_description_type":"Abstract"},{"subitem_description":"PYNOD(Nlrp10) is one of the NLR family member we recently identified, however, the physiological function of PYNOD is still totally unclear. To investigate physiological/pathological function of PYNOD, we succeeded to establish PYNOD deficient mice. We found that keratinocytes from PYNOD deficient mice show lower potential to produce TNFαafter UVB treatment than that of wild-type mice. We further found TNFαproduction in skin after UVB treatment also decreased in PYNOD deficient mice. Moreover, we discovered IFNγproduction in serum after UVB treatment is higher in PYNOD deficient mice. These results suggest that PYNOD plays important roles to produce TNFαproduction after UVB treatment in skin and contributes local inflammatory responses.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:21590329, 研究期間(年度):2008-2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「皮膚におけるASCおよびPYNODの機能の解明」課題番号21590329\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21590329/21590329seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050112","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学がん進展制御研究所"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10311680"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10311680","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590329/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590329/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21590329/21590329seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21590329/21590329seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-15"}],"displaytype":"detail","filename":"CA-PR-IMAMURA-R-kaken 2012-6p.pdf","filesize":[{"value":"216.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-IMAMURA-R-kaken 2012-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43770/files/CA-PR-IMAMURA-R-kaken 2012-6p.pdf"},"version_id":"19d0f7aa-1998-4905-bd54-a73c6d0f83c8"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"皮膚におけるASCおよびPYNODの機能の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"皮膚におけるASCおよびPYNODの機能の解明"},{"subitem_title":"Analyses of function of ASC and PYNOD in skin","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-15"},"publish_date":"2018-02-15","publish_status":"0","recid":"43770","relation_version_is_last":true,"title":["皮膚におけるASCおよびPYNODの機能の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:28:31.766884+00:00"}