{"created":"2023-07-27T06:50:44.449058+00:00","id":43773,"links":{},"metadata":{"_buckets":{"deposit":"b8a7e028-7895-4f87-8fd4-1f1142d90955"},"_deposit":{"created_by":18,"id":"43773","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43773"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043773","sets":["2812:2813:2818"]},"author_link":["536","85742"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2013-04-01 – 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"DNA損傷チェックポイント因子ATMは、DNA損傷に対する細胞応答に加えて、グリオーマの悪性化に重要となるエネルギー代謝経路に対し、AMPKのリン酸化の制御を介して関与していることを明らかにした。このエネルギー代謝経路、特に、ミトコンドリアによるエネルギー合成経路は、mTORC1活性の高い悪性グリオーマの治療標的として利用できる可能性を示した。","subitem_description_type":"Abstract"},{"subitem_description":"ATM is involved in the regulation of energy metabolism, which is important for malignancy of glioma, via AMPK phosphorylation in addition to its DNA damage response. This energy metabolism pathway, especially mitochondrial energy production, may be an effective therapeutic target for glioma patients.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25340028, 研究期間(年度):2013-04-01 – 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「DNA損傷を介さないATM依存的な細胞ストレス応答と発がん抑制機構の解析」課題番号25340028\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25340028/25340028seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050115","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70285633"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70285633","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25340028/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25340028/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25340028/25340028seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25340028/25340028seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-15"}],"displaytype":"detail","filename":"CA-PR-KOBAYASHI-M-kaken 2016-4p.pdf","filesize":[{"value":"166.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-KOBAYASHI-M-kaken 2016-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43773/files/CA-PR-KOBAYASHI-M-kaken 2016-4p.pdf"},"version_id":"2a20f52e-cb78-42cd-ae2d-8d96d18e45e6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"DNA損傷を介さないATM依存的な細胞ストレス応答と発がん抑制機構の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"DNA損傷を介さないATM依存的な細胞ストレス応答と発がん抑制機構の解析"},{"subitem_title":"Involvement of DNA damage-independent and ATM-dependent stress response in tumor suppressive mechanism","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-15"},"publish_date":"2018-02-15","publish_status":"0","recid":"43773","relation_version_is_last":true,"title":["DNA損傷を介さないATM依存的な細胞ストレス応答と発がん抑制機構の解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:57:12.415102+00:00"}