{"created":"2023-07-27T06:50:45.383065+00:00","id":43794,"links":{},"metadata":{"_buckets":{"deposit":"3c21e921-ec4b-4b4d-8cd6-66901bc7e05a"},"_deposit":{"created_by":18,"id":"43794","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43794"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043794","sets":["2812:2813:2817"]},"author_link":["72132","15656"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2014-04-01 – 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"最近の研究により、造血幹細胞は極めて多様な生物活性を持ったヘテロな集団であることが判明している。生体はこの造血幹細胞の不均一性を維持することで、造血システムを長期間維持し、様々なストレスに対応していると考えられる。本研究では、分裂活性や細胞周期制御に極めて重要なmTORキナーゼ複合体とフォークヘッド転写因子Foxoに着目し、これらの分子に制御を受ける遺伝子を網羅的に解析した。さらに、CRISPR/Cas9を利用した分子機能スクリーニングを実施することで、造血幹細胞や白血病幹細胞の不均一性に寄与する分子経路を複数同定した。 ","subitem_description_type":"Abstract"},{"subitem_description":"Recent studies have revealed that hematopoietic stem cells (HSCs) form heterogeneous population with extremely diverse biological properties. By maintaining the heterogeneity, HSCs maintain the hematopoietic system for whole life, and it seems that it contributes to respond to various stresses. In this study, we focused on mTOR complex and forkhead transcription factor, FOXO, which are essential for survival and cell cycle regulation, and we identified molecules that are regulated by these pathways. Furthermore, by performing CRISPR/Cas9 screening system, we identified multiple functional molecules that contribute to regulate heterogeneity of HSCs and leukemic stem cells.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26460361, 研究期間(年度):2014-04-01 – 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「静止期制御因子を指標とした造血幹細胞不均一性の解明」研究成果報告書　課題番号26460361\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26460361/26460361seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050136","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20334766"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20334766","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26460361/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26460361/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26460361/26460361seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26460361/26460361seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-11"}],"displaytype":"detail","filename":"CA-PR-UENO-M-kaken 2017-5p.pdf","filesize":[{"value":"79.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-UENO-M-kaken 2017-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43794/files/CA-PR-UENO-M-kaken 2017-5p.pdf"},"version_id":"fc149d73-e194-4d85-870e-3a105f7f4587"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"静止期制御因子を指標とした造血幹細胞不均一性の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"静止期制御因子を指標とした造血幹細胞不均一性の解明"},{"subitem_title":"Understanding of the molecular mechanisms of hematopoietic stem cell heterogeneity by quiescence regulatory factors","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-11"},"publish_date":"2018-06-11","publish_status":"0","recid":"43794","relation_version_is_last":true,"title":["静止期制御因子を指標とした造血幹細胞不均一性の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:34:15.744579+00:00"}