{"created":"2023-07-27T06:50:45.427676+00:00","id":43795,"links":{},"metadata":{"_buckets":{"deposit":"cfbf6b54-ecb9-46f5-be2c-e4d3b8f71981"},"_deposit":{"created_by":18,"id":"43795","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43795"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043795","sets":["2812:2813:2818"]},"author_link":["2843","85743"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-23","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2013-04-01 – 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究はGSK3βのがん促進作用のメカニズムをがん固有の代謝特性に焦点を当てて検討した．大腸がん細胞で異常活性を示すGSK3βはピルビン酸脱水素酵素（PDH）を特異的にリン酸化してその活性を阻害することにより，がん促進的に作用する解糖系優位の代謝を誘導していると考えられた．GSK3β阻害により，がん細胞のエネルギー産生経路は解糖系から酸化的リン酸化にシフトし，アポトーシス刺激感受性になった．一方，これらの代謝変化は非腫瘍性細胞では認められなかった．したがって，GSK3β阻害によるがん治療効果はがん特有のエネルギー代謝を選択的に是正することによるものと考えられ，その安全性を示唆している.","subitem_description_type":"Abstract"},{"subitem_description":"We have identified aberrant GSK3beta as an attractive therapeutic target in various cancer types. Here we explored the mechanism for the tumor-promoting role of GSK3beta by focusing on the distinct energy metabolic property in cancer. We found that GSK3beta deregulated in cancer cells and their xenografts phosphorylates and inactivates pyruvate dehydrogenase (PDH)-E1alpha, the active subunit of PDH. This results in induction of the aerobic glycolysis that preferentially fuels cancer cells, leading to progression of cancer. Inhibition of GSK3beta shifted the energy source of cancer cells from glycolysis to oxidative phosphorylation in mitochondria, rendering them susceptible to apoptotic insults. No such metabolic changes were observed in non-neoplastic cells or rodent’s liver. Our results suggests that cancer therapeutic effect of GSK3beta inhibition depends on the exclusive metabolic shift in cancer cells, which reinforces the safety of targeting GSK3beta for cancer treatment.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25860233, 研究期間(年度):2013-04-01 – 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「エネルギー代謝特性に基づく消化器がん病態解明と制御への応用」課題番号25860233\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25860233/25860233seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050137","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80635540"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80635540","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25860233/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25860233/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25860233/25860233seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25860233/25860233seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-16"}],"displaytype":"detail","filename":"CA-PR-DOMOTO-T-kaken 2016-4p.pdf","filesize":[{"value":"194.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-DOMOTO-T-kaken 2016-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43795/files/CA-PR-DOMOTO-T-kaken 2016-4p.pdf"},"version_id":"f0dff1fb-0cef-4f22-bc52-8d16d0e46167"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"エネルギー代謝特性に基づく消化器がん病態解明と制御への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"エネルギー代謝特性に基づく消化器がん病態解明と制御への応用"},{"subitem_title":"Exploring biological basis of aberrant energy metabolic property of gastrointestinal cancer toward application to cancer treatment","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-16"},"publish_date":"2018-02-16","publish_status":"0","recid":"43795","relation_version_is_last":true,"title":["エネルギー代謝特性に基づく消化器がん病態解明と制御への応用"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:57:10.898176+00:00"}