{"created":"2023-07-27T06:50:45.561963+00:00","id":43798,"links":{},"metadata":{"_buckets":{"deposit":"0612bd7d-d015-47f4-be06-708b6279383d"},"_deposit":{"created_by":18,"id":"43798","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43798"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043798","sets":["2812:2813:2823"]},"author_link":["47725","1910"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05-23","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2009-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、レトロウイルス挿入変異法によって同定された新規がん関連遺伝子候補、Jmjd5(ヒストン脱メチル化酵素をコード)について変異マウスを作製し、個体レベルでの生理機能・がん発症との関わりを調べ、発生過程に必須な因子の1つであることが証明された。つまりJmjd5はCdkn1a(p21)の発現量を負に制御することで胚細胞の正常な増殖に貢献することが明らかとなった。","subitem_description_type":"Abstract"},{"subitem_description":"In order to identify novel cancer-related genes, we have performed the retroviral insertional mutagenesis in mice, resulting in identification of Jmjd5, a histone demethylase. In this study, we have generated Jmjd5-deficient mice to investigate in vivo role of Jmjd5. Our results showed that Jmjd5 was involved in embryonic cell proliferation and that Cdkn1a might be one of Jmjd5 targets.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:21790178, 研究期間(年度):2009-2010","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「新規がん抑制遺伝子候補Jmjd5の血管新生・造血における役割と発がん機構の解明」課題番号21790178\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21790178/21790178seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050140","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80375261"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80375261","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790178/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790178/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21790178/21790178seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21790178/21790178seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-16"}],"displaytype":"detail","filename":"CA-PR-ISHIMURA-A-kaken 2011-4p.pdf","filesize":[{"value":"345.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-ISHIMURA-A-kaken 2011-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43798/files/CA-PR-ISHIMURA-A-kaken 2011-4p.pdf"},"version_id":"c17a431f-7981-45bf-a46a-ef0f613f9601"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"新規がん抑制遺伝子候補Jmjd5の血管新生・造血における役割と発がん機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規がん抑制遺伝子候補Jmjd5の血管新生・造血における役割と発がん機構の解明"},{"subitem_title":"Functional analysis of Jmjd5, a candidate tumor suppressor gene, for angiogenesis, hematopoiesis and tumorigenesis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-16"},"publish_date":"2018-02-16","publish_status":"0","recid":"43798","relation_version_is_last":true,"title":["新規がん抑制遺伝子候補Jmjd5の血管新生・造血における役割と発がん機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:18:13.989287+00:00"}