{"created":"2023-07-27T06:50:45.652087+00:00","id":43801,"links":{},"metadata":{"_buckets":{"deposit":"5f7c4d17-bae7-4088-866b-28eec0f5c32d"},"_deposit":{"created_by":18,"id":"43801","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43801"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043801","sets":["2812:2813:2818"]},"author_link":["85783","85781"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05-25","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2014-08-29 – 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 研究活動スタート支援 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"これまでレトロウイルス挿入変異により癌を発症したマウスから、その挿入部位を同定することにより、癌に関わる遺伝子候補が多数同定されてきた。申請者はタンパク質をコードしないnon-coding RNAもウイルス挿入標的となっており、癌に関わる遺伝子候補であることを見出した。それらのうち、急性前骨髄球性白血病での関与が推測されているNEAT1、X染色体の不活性化に関わるJPXは悪性度の高い乳癌患者、および悪性度の高い癌微小環境の1つである低酸素条件下において、その発現が低下していた。これらの結果はNEAT1、およびJPXの発現低下が乳癌の悪性化に関わる可能性を示唆している。","subitem_description_type":"Abstract"},{"subitem_description":"Many cancer-related genes were identified by retroviral insertional mutagenesis. We also found non-coding RNAs are targets of retroviral integration and are therefore involved in cancer. Among them, we focused on two non-coding RNAs, NEAT1 and JPX. Previous studies showed that NEAT1 can be involved in acute promyelocytic leukemia and JPX is involved in the regulation of X chromosome inactivation. In this study, we found that NEAT1 and JPX were downregulated in high grade breast cancer patients and were downregulated in hypoxia that can enhance tumor progression. These findings suggest that downregulated-NEAT1 and downregulated-JPX may be involved in breast cancer progression.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26893093, 研究期間(年度):2014-08-29 – 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「がん発症、悪性化におけるnon-coding RNAの新しい役割」課題番号26893093\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26893093/26893093seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050143","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80507434"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80507434","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26893093/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26893093/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26893093/26893093seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26893093/26893093seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-16"}],"displaytype":"detail","filename":"CA-PR-TERASHIMA-M-kaken 2016-4p.pdf","filesize":[{"value":"255.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-TERASHIMA-M-kaken 2016-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43801/files/CA-PR-TERASHIMA-M-kaken 2016-4p.pdf"},"version_id":"1ddbd9e9-c6c1-4449-a394-7092677991a6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"がん発症、悪性化におけるnon-coding RNAの新しい役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"がん発症、悪性化におけるnon-coding RNAの新しい役割"},{"subitem_title":"The role of non-coding RNA in cancer initiation and cancer progression","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-16"},"publish_date":"2018-02-16","publish_status":"0","recid":"43801","relation_version_is_last":true,"title":["がん発症、悪性化におけるnon-coding RNAの新しい役割"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:57:08.617409+00:00"}