{"created":"2023-07-27T06:50:46.190031+00:00","id":43866,"links":{},"metadata":{"_buckets":{"deposit":"4a79e98b-4831-4e67-8d92-a115acda0a94"},"_deposit":{"created_by":18,"id":"43866","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43866"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043866","sets":["2812:2813:2817"]},"author_link":["72412","65"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2015-04-01 – 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"核移行成分のないβ-カテニンの細胞質-核間移行の仕組みを理解する目的で，分子の核移送に機能する核膜孔複合体因子(Nups)とβ-カテニンの発現や相互作用を調べた．正常細胞，大腸がん細胞と大腸がん症例のがん，正常粘膜を対象にNupsの発現を比べ，がん細胞である種のNup(NupX)の発現がβ-カテニン核集積と逆相関することを見いだした．大腸がん細胞でβ-カテニンとT細胞因子4の抗体により免疫沈降するNupsのうちの1つがNupXであった．大腸がん組織における発現解析とがん細胞における機能解析により，NupXはβ-カテニンの核排出に作用し，大腸がんのWnt経路には抑制的に作用することが示唆された．  ","subitem_description_type":"Abstract"},{"subitem_description":"To understand the mechanism by which β-catenin with no nuclear localization signal transits between cytoplasm and nucleus, this study investigated expression of and interaction between β-catenin and nucleoporins (Nups) that constitute nuclear pore complex and participate in nucleocytoplasmic trafficking of various functional macro-molecules. Comparative analysis of expression of 30 Nups in normal cells, colon cancer cell lines, human colorectal cancer (CRC) tissues and the non-neoplastic mucosa found an inverse association between the expression of a certain Nup (here called NupX) and the nuclear accumulation of β-catenin in colon cancer cells and CRC tissues. Subsequent analysis identified NupX among Nups coimmunoprecipitated with β-catenin and T-cell factor (Tcf)4 in protein extracts from colon cancer SW480 and HCT116 cells. Analysis of its expression and function indicated that NupX functions to excrete β-catenin from nucleus, thereby inactivating the Wnt signal pathway in CRC.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K15493, 研究期間(年度):2015-04-01 – 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「大腸がんにおけるβ-カテニン核移送に作用する核膜孔複合体因子の探索と機能解析」研究成果報告書　課題番号15K15493\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K15493/15K15493seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050208","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50239323"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50239323","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15493/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15493/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K15493/15K15493seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K15493/15K15493seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-11"}],"displaytype":"detail","filename":"CA-PR-MINAMOTO-T-kaken 2017-4p.pdf","filesize":[{"value":"713.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-MINAMOTO-T-kaken 2017-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43866/files/CA-PR-MINAMOTO-T-kaken 2017-4p.pdf"},"version_id":"c5bc2f1b-3601-4d60-99ab-de923ffb692b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"大腸がんにおけるβ-カテニン核移送に作用する核膜孔複合体因子の探索と機能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"大腸がんにおけるβ-カテニン核移送に作用する核膜孔複合体因子の探索と機能解析"},{"subitem_title":"Identification and functional analysis of nuclear pore complex components that function to transport beta-catenin between cytoplasm and nucleus","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-11"},"publish_date":"2018-06-11","publish_status":"0","recid":"43866","relation_version_is_last":true,"title":["大腸がんにおけるβ-カテニン核移送に作用する核膜孔複合体因子の探索と機能解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:34:18.785298+00:00"}