{"created":"2023-07-27T06:50:46.234159+00:00","id":43867,"links":{},"metadata":{"_buckets":{"deposit":"f0122d05-8f8f-4821-bbb5-c99408ccfc67"},"_deposit":{"created_by":18,"id":"43867","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43867"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043867","sets":["2812:2813:2816"]},"author_link":["72411","72412"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-09-11","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2015-04-01 – 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"グリコーゲン合成酵素キナーゼ（GSK）3βと大腸がん病態の関連をがんの代謝特性やmicro(mi)-RNAなどに着目して解析した。GSK3βは70%の大腸がん症例の腫瘍で発現亢進し、let-7 miRNAの発現と逆相関したが、K-rasやSrcの活性とは相関しなかった。大腸がん細胞と腫瘍組織の代謝における機能解析から、GSK3βはがん促進的な代謝を誘導することを見いだした。GSK3β標的療法のがん治療への応用のため、阻害剤シード化合物の効果の予備検討を行った。","subitem_description_type":"Abstract"},{"subitem_description":"We explored the biological role of glycogen synthase kinase (GSK)3β in colorectal cancer (CRC) progression by focusing on the distinct metabolic profile and micro(mi)-RNA. Expression of GSK3β was increased in 70% of clinical CRC tumors, which was associated inversely with expression of tumor suppressive let-7 miRNA but not with activation of K-ras or Src oncoprotein. Metabolic analysis of GSK3β in CRC cells and tumors found that GSK3β was responsible for tumor-promoting aberrant metabolism. For translation of GSK3β-targeted therapy to cancer treatment, we also conducted preliminary studies on cancer therapeutic effects of GSK3β-inhibiting seed compounds.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15H04928, 研究期間(年度):2015-04-01 – 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「GSK3β経路を標的とする大腸がんの病態解明と治療法開発の基盤形成」課題番号15H04928\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15H04928/15H04928seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050209","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50239323"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50239323","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04928/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04928/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15H04928/15H04928seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15H04928/15H04928seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-06"}],"displaytype":"detail","filename":"CA-PR-MINAMOTO-T-kaken 2018-6p.pdf","filesize":[{"value":"835.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-MINAMOTO-T-kaken 2018-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43867/files/CA-PR-MINAMOTO-T-kaken 2018-6p.pdf"},"version_id":"5a149d40-b5c5-4bf5-a6ac-b6741c3cbeb6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"GSK3β経路を標的とする大腸がんの病態解明と治療法開発の基盤形成","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"GSK3β経路を標的とする大腸がんの病態解明と治療法開発の基盤形成"},{"subitem_title":"Investigation of biological basis of GSK3beta-targeted therapy and its translation to colorectal cancer treatment","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-06"},"publish_date":"2019-04-06","publish_status":"0","recid":"43867","relation_version_is_last":true,"title":["GSK3β経路を標的とする大腸がんの病態解明と治療法開発の基盤形成"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:03:25.630673+00:00"}