{"created":"2023-07-27T06:50:46.636834+00:00","id":43876,"links":{},"metadata":{"_buckets":{"deposit":"9441771c-ded4-4989-8acd-39c22279eea5"},"_deposit":{"created_by":18,"id":"43876","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43876"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043876","sets":["2812:2813:2823"]},"author_link":["457","85792"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2009-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、Sirp・^・胸腺樹状細胞(tDC)サブセットの分化誘導、胸腺内局在、機能的特徴について解析を行なった結果、Sirp・^<・・>tDCは、ケモカインレセプターであるCCR2を介したシグナルにより、胸腺内への動員、局在性が制御されており、胸腺皮質領域や傍血管領域(PVR)に散在性に分布していることを明らかにした。さらにその特徴的な局在性から、血液中のタンパクを選択的に取り込み、未熟T前駆細胞に対して、抗原を提示することで、制御性T細胞への分化を誘導することを明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"In this study, we investigated the mechanism of differentiation, intrathymic localization, and distinctive function of Sirp・^<・・>tDCs in central tolerance. Our observation revealed that Sirp・^<・・> tDCs were disseminated in the thymic cortical area, with some of them uniquely localized inside PVRs. Moreover, Sirp・^<・・> cDC subset can selectively capture blood-borne antigens under the multi-step guidance of CCR2-mediated signals. Furthermore, they can present blood-borne antigens to the majority of immature thymocytes to induce antigen-specific Treg generation.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:21790464, 研究期間(年度):2009-2010","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「胸腺Sirp・^+樹状細胞の機能的特徴と自己免疫寛容における役割の解明」課題番号21790464\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21790464/21790464seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050218","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00452095"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00452095","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790464/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790464/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21790464/21790464seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21790464/21790464seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-19"}],"displaytype":"detail","filename":"CA-PR-BABA-T-kaken 2011-4p.pdf","filesize":[{"value":"250.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-BABA-T-kaken 2011-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43876/files/CA-PR-BABA-T-kaken 2011-4p.pdf"},"version_id":"763d3b84-b8ae-4bda-96c3-8c2139c011e1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"胸腺Sirp・^+樹状細胞の機能的特徴と自己免疫寛容における役割の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胸腺Sirp・^+樹状細胞の機能的特徴と自己免疫寛容における役割の解明"},{"subitem_title":"Research of biological function and distinctive role of Sirp・^+ dendritic cells in central tolerance","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-16"},"publish_date":"2018-02-16","publish_status":"0","recid":"43876","relation_version_is_last":true,"title":["胸腺Sirp・^+樹状細胞の機能的特徴と自己免疫寛容における役割の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:18:12.567013+00:00"}