{"created":"2023-07-27T06:50:52.917317+00:00","id":44042,"links":{},"metadata":{"_buckets":{"deposit":"f4995fbf-0518-43b3-8b3f-8591a1a54461"},"_deposit":{"created_by":18,"id":"44042","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44042"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044042","sets":["2812:2813:2827"]},"author_link":["73700","73699"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-03","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"39p.","bibliographicVolumeNumber":"2005-2006","bibliographic_titles":[{"bibliographic_title":"平成18(2006)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2006 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究は、短時間のPEEP負荷の(1)腎虚血再灌流障害の制御に対する効果、(2)腎組織熱ショック蛋自の誘導条件、(3)流血中熱ショック蛋白に対する影響を検討し、(4)短時間のPEEP負荷が敗血症ショックモデルのサイトカイン産生や血行動態の制御効果を検討するととともに、効果をサイトカイン除去療法と比較し、(5)臨床症例における血中熱ショック蛋白濃度と疾患、高PEEP負荷の関係を明らかにすることを目的とした。[結果](1)PEEP前処置は腎虚血再灌流障害を有意に抑制した。この効果はPEEPによる循環変動(低血圧)のみでは説明できない。(2)PEEPの負荷は圧・時間依存性に腎組織HSP72陽性細胞数を増加させたが、血中HSP72を検出範囲に増加さなかった。(3)PEEPによるHO-1の誘導効果は明らかでない。(4)除去カラムによるサイトカイン除去療法は敗血症ショックモデルに対し容量依存性効果を示した。しかし、腎虚血に対し有効であったPEEP前処置は、敗血症ショックモデルに対し有意の影響を与えなかった。(5)HSP72濃度は高いPEEP負荷とは有意に関係せず、原疾患により影響された。(6)血中ストレス蛋白濃度は蘇生された心停止例の予後を反映する可能性がある。[結論]短時問のPEEP負荷は腎虚血に対し防御効果を発揮するが、敗血症に対しては有意な影響を与えなかった。 ","subitem_description_type":"Abstract"},{"subitem_description":"Pretreatment with PEEP significantly attenuated the renal ischemia-reperfusion injuries in rats. This effect of PEEP was not solely attributed to the hemodynamic effects of PEEP. The PEEP administration increased HSP72-expressed cells in the kidney in time-and level-dependent manners. It remains uncertain whether the PEEP administration may induce other heat shock proteins in the renal cells. Pretreatment with high PEEP did not significantly influence either the plasma TNF-alpha, 11-6 and 11-10 levels or hemodynamic variables after endotoxin administration. In contrast, removal of cytokines with CTR column significantly decreased the mortality and attenuated the changes in hemodynamics and plasma cytokine levels in rat septic models. In critically ill patients, plasma HSP72 levels were not correlated with the application of PEEP. Heat shock protein may be useful to evaluate the prognosis in patient resuscitated from cardiac arrests.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:17591885, 研究期間(年度):2005-2006","subitem_description_type":"Other"},{"subitem_description":"出典：「PEEPの短時間負荷により誘導される熱ショック蛋白を利用した敗血症の制御」研究成果報告書　課題番号17591885\n  (KAKEN：科学研究費助成事業データベース（国立情報学研究所）)\n　　　本文データは著者版報告書より作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050384","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60159952"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60159952","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17591885/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17591885/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17591885/175918852006kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17591885/175918852006kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-19"}],"displaytype":"detail","filename":"ME-PR-INABA-H-kaken 2007-39p.pdf","filesize":[{"value":"5.4 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-INABA-H-kaken 2007-39p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44042/files/ME-PR-INABA-H-kaken 2007-39p.pdf"},"version_id":"be6505c8-3550-481b-ac8e-6f7d46183578"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"PEEPの短時間負荷により誘導される熱ショック蛋白を利用した敗血症の制御","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PEEPの短時間負荷により誘導される熱ショック蛋白を利用した敗血症の制御"},{"subitem_title":"Control of sepsis with heat shock protein induced by high PEEP","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2827"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-03-19"},"publish_date":"2018-03-19","publish_status":"0","recid":"44042","relation_version_is_last":true,"title":["PEEPの短時間負荷により誘導される熱ショック蛋白を利用した敗血症の制御"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:34:24.126614+00:00"}