{"created":"2023-07-27T06:50:53.049810+00:00","id":44046,"links":{},"metadata":{"_buckets":{"deposit":"464d0e48-85eb-4cd6-af9c-71823e7b41b2"},"_deposit":{"created_by":18,"id":"44046","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44046"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044046","sets":["2812:2813:2818"]},"author_link":["73706","73705"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05-11","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2013-04-01 – 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"播種性血管内凝固症候群（DIC）は、基礎疾患の存在下に全身性持続性の著しい凝固活性化をきたし、微小血栓の多発する重篤な病態である。予後改善のためには、より良い診断基準の作成と、病態に応じた治療介入が必要である。動物DICモデルにおいては、LPSまたは組織因子（TF）のいずれで誘発するのか区別されることなく使用されてきたが、我々は両モデル間に、凝固線溶病態のみならず炎症や血管作動性物質の観点からも大きな差違が見られることを解明した。","subitem_description_type":"Abstract"},{"subitem_description":"Disseminated intravascular coagulation (DIC) is a serious disease that, in the presence of underlying disease, causes persistent, generalized, marked coagulation activation. Early treatment based on an appropriate diagnosis is very important for improving patients’ prognosis.\nThe commonly used conventional animal models of DIC are induced with LPS or tissue factor (TF), and they have been considered to be essentially the same pathologically. However, our group recently showed that the pathology differs greatly depending on the DIC inducer used, at the view point of coagulofibrinolytic activation, inflammation and vasoactive substances.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25462818, 研究期間(年度):2013-04-01 – 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「DICにおける炎症と凝固の相互作用遮断と血管作動性物質」課題番号25462818\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25462818/25462818seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院高密度無菌治療部","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050388","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60192936"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60192936","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25462818/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25462818/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25462818/25462818seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25462818/25462818seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-19"}],"displaytype":"detail","filename":"ME-PR-ASAKURA-H-kaken 2016-6p.pdf","filesize":[{"value":"279.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-ASAKURA-H-kaken 2016-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44046/files/ME-PR-ASAKURA-H-kaken 2016-6p.pdf"},"version_id":"1aa2eda2-e731-456e-9345-8d5ae0282ca3"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"DICにおける炎症と凝固の相互作用遮断と血管作動性物質","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"DICにおける炎症と凝固の相互作用遮断と血管作動性物質"},{"subitem_title":"Blocking the interaction of coagulation and inflammation, and significance of vasoactive substances in DIC","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-03-19"},"publish_date":"2018-03-19","publish_status":"0","recid":"44046","relation_version_is_last":true,"title":["DICにおける炎症と凝固の相互作用遮断と血管作動性物質"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:57:02.480756+00:00"}