{"created":"2023-07-27T06:50:53.093659+00:00","id":44054,"links":{},"metadata":{"_buckets":{"deposit":"4e8b5f9d-e724-4a4d-ad70-fa42ad680af6"},"_deposit":{"created_by":18,"id":"44054","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44054"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044054","sets":["2812:2813:2822"]},"author_link":["73706","73705"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-04-19","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2009-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"LPS誘発播種性血管内凝固症候群(DIC)モデルに対して、凝固と炎症の相互作用を遮断する目的で、エリスロポイエチン、CO供給物質、HO-1阻害剤(SnPP)を投与して、血液凝固、線溶、臓器障害、血管作動性物質、病理所見(血栓)、mRNAに対する影響を検討した。薬物用量や臓器毎によって違った影響が観察されたが、凝固や線溶に直接影響を及ぼさないこれらの薬物であっても、DIC治療薬として展望があると考えられた。","subitem_description_type":"Abstract"},{"subitem_description":"We investigated the effect of erythropoietin, carbon monoxide release molecule and SnPP that may be able to interrupt interaction between coagulation and inflammation, on LPS-induced rat DIC model. The estimated markers were blood coagulation, fibrinolysis, organ injury, vasoactive substances, pathological findings and the mRNA expression of hemostatic substances. Although the effect of these drugs were different among doses or organs, such drugs without the influence on coagulation and fibrinolysis were expected as new DIC drugs.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「播種性血管内凝固における炎症と凝固の相互作用と血管作動性物質の関与」課題番号21590614\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21590614/21590614seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050396","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学附属病院高密度無菌治療部"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60192936"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60192936","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590614/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590614/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21590614/21590614seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21590614/21590614seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-19"}],"displaytype":"detail","filename":"ME-PR-ASAKURA-H-kaken 2012-5p.pdf","filesize":[{"value":"208.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-ASAKURA-H-kaken 2012-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44054/files/ME-PR-ASAKURA-H-kaken 2012-5p.pdf"},"version_id":"0f7b7529-197d-407a-b111-31fc933a48f4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"播種性血管内凝固における炎症と凝固の相互作用と血管作動性物質の関与","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"播種性血管内凝固における炎症と凝固の相互作用と血管作動性物質の関与"},{"subitem_title":"Significance of the vasoactive substances and interaction between inflammation and coagulation in DIC","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-03-19"},"publish_date":"2018-03-19","publish_status":"0","recid":"44054","relation_version_is_last":true,"title":["播種性血管内凝固における炎症と凝固の相互作用と血管作動性物質の関与"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:28:34.447908+00:00"}