{"created":"2023-07-27T06:50:53.315542+00:00","id":44059,"links":{},"metadata":{"_buckets":{"deposit":"e86db3eb-10c8-4697-89b5-70112c319be0"},"_deposit":{"created_by":18,"id":"44059","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44059"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044059","sets":["2812:2813:2823"]},"author_link":["26970","69579"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-04-10","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2008-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"食細胞による要除去細胞の貪食は,細胞性自然免疫であり,この貪食機構と意義を明らかにすることが求められていた。本研究では,哺乳動物とショウジョウバエの食細胞について,貪食受容体を介する細胞内情報経路を同定した。また貪食誘導性受容体のリガンドを同定し,微生物と自己変性細胞とでそれぞれ異なる分子を認識するマルチリガンド受容体であると考えられた。さらに,宿主の液性および細胞性免疫応答に作用する,細菌の細胞壁成分を同定し,その働きから,細菌が宿主免疫を回避する抵抗機構の存在がわかった。","subitem_description_type":"Abstract"},{"subitem_description":"Elimination of unwanted cells by phagocytosis is the cellular innate immunity, and its molecular mechanism and role have remained to be elucidated. In this study, we found out the intracellular signaling through Draper, a phagocytic receptor we have detected. We also identified Draper ligand in Drosophila apoptotic cells and bacteria, and suggested that the phagocytic receptor in innate immunity acts as a multi ligand-receptor. On the other hand, we identified bacterial factors that influenced with host cellular and humoral immunity, and examined bacterial strategy to escape from the host immune responses.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「微生物および変性自己細胞の食細胞による貪食機構と意義」課題番号20570127\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20570127/20570127seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050401","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=90303297"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=90303297","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20570127/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20570127/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20570127/20570127seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20570127/20570127seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-19"}],"displaytype":"detail","filename":"PH-PR-SHIRATSUCHI-A-kaken 2011-6p.pdf","filesize":[{"value":"198.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-SHIRATSUCHI-A-kaken 2011-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44059/files/PH-PR-SHIRATSUCHI-A-kaken 2011-6p.pdf"},"version_id":"6b2c8d07-b78e-46cb-928c-3e2ac5f46b7f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"微生物および変性自己細胞の食細胞による貪食機構と意義","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"微生物および変性自己細胞の食細胞による貪食機構と意義"},{"subitem_title":"Mechanisms and roles on phagocytosis of microbes and altered self cells","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-03-19"},"publish_date":"2018-03-19","publish_status":"0","recid":"44059","relation_version_is_last":true,"title":["微生物および変性自己細胞の食細胞による貪食機構と意義"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:18:11.248873+00:00"}