{"created":"2023-07-27T06:50:56.471819+00:00","id":44140,"links":{},"metadata":{"_buckets":{"deposit":"688b7a07-ad17-4931-b791-da0ce94120f5"},"_deposit":{"created_by":18,"id":"44140","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44140"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044140","sets":["1132:1133:1134"]},"author_link":["73992","73997","73989","73999","73991","73994","73993","74000","45863","73995","73998","22954"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-07","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"149","bibliographicPageStart":"137","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"EBioMedicine"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"長田, 直人"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"金子, 周一"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"太田, 嗣人"}],"nameIdentifiers":[{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Sodium-glucose cotransporter (SGLT) 2 inhibitors increase urinary glucose excretion (UGE), leading to blood glucose reductions and weight loss. However, the impacts of SGLT2 inhibition on energy homeostasis and obesity-induced insulin resistance are less well known. Here, we show that empagliflozin, a SGLT2 inhibitor, enhanced energy expenditure and attenuated inflammation and insulin resistance in high-fat-diet-induced obese (DIO) mice. C57BL/6J mice were pair-fed a high-fat diet (HFD) or a HFD with empagliflozin for 16 weeks. Empagliflozin administration increased UGE in the DIO mice, whereas it suppressed HFD-induced weight gain, insulin resistance, and hepatic steatosis. Moreover, empagliflozin shifted energy metabolism towards fat utilization, elevated AMP-activated protein kinase and acetyl-CoA carbolxylase phosphorylation in skeletal muscle, and increased hepatic and plasma fibroblast growth factor 21 levels. Importantly, empagliflozin increased energy expenditure, heat production, and the expression of uncoupling protein 1 in brown fat and in inguinal and epididymal white adipose tissue (WAT). Furthermore, empagliflozin reduced M1-polarized macrophage accumulation while inducing the anti-inflammatory M2 phenotype of macrophages within WAT and liver, lowering plasma TNFα levels and attenuating obesity-related chronic inflammation. Thus, empagliflozin suppressed weight gain by enhancing fat utilization and browning and attenuated obesity-induced inflammation and insulin resistance by polarizing M2 macrophages in WAT and liver.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050482","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.ebiom.2017.05.028","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.elsevier.com/locate/issn/23523964"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.elsevier.com/locate/issn/23523964","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © Elsevier (CC-BY-NC-ND)"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2352-3964","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Xu, Liang"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagata, Naoto"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Nagashimada, Mayumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Zhuge, Fen"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ni, Yinhua"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Chen, Guanliang"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mayoux, Eric"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kaneko, Shuichi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Ota, Tsuguhito"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-04-06"}],"displaytype":"detail","filename":"ME-PR-NAGATA-N-137.pdf","filesize":[{"value":"3.0 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NAGATA-N-137.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44140/files/ME-PR-NAGATA-N-137.pdf"},"version_id":"68bd3168-be6a-4763-8532-dbb546978237"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese Mice.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese Mice."}]},"item_type_id":"4","owner":"18","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-06"},"publish_date":"2018-04-06","publish_status":"0","recid":"44140","relation_version_is_last":true,"title":["SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese Mice."],"weko_creator_id":"18","weko_shared_id":18},"updated":"2023-07-27T16:56:49.569198+00:00"}