{"created":"2023-07-27T06:50:56.694897+00:00","id":44145,"links":{},"metadata":{"_buckets":{"deposit":"f71aa227-0943-498d-bb57-269c7df30c0c"},"_deposit":{"created_by":18,"id":"44145","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44145"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044145","sets":["1132:1133:1134"]},"author_link":["74060","74057","74047","74061","74059","74048","74064","21777","74055","74058","74052","74062","22954","70285","74045","74049","74050","70236","74046","74051","74043","74063"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"2174","bibliographicPageStart":"2163","bibliographicVolumeNumber":"47","bibliographic_titles":[{"bibliographic_title":"European Journal of Immunology"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"酒井, 佳夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"餅田, 初音"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"吉田, 佳子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"高村, 雅之"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"薄井, 荘一郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"和田, 隆志"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"本多, 政夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"金子, 周一"}],"nameIdentifiers":[{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Stromal cells in adipose tissue are useful for repair/regenerative therapy as they harbor a substantial number of mesenchymal stem cells; therefore, freshly isolated autologous uncultured adipose tissue derived stromal cells (u-ADSCs) are useful for regenerative therapy, and obviate the need for mesenchymal stem cells. We evaluated the therapeutic effect of murine u-ADSCs and sorted subsets of u-ADSCs in a concanavalin A (ConA) induced murine model of hepatitis, as well as their characteristics. We found that 10–20% of u-ADSCs expressed the CD45 leukocyte-related antigen. CD68, which is a marker of macrophages (MΦs), was expressed by 50% of CD45+ u-ADSCs. About 90% of CD68+CD45+ cells expressed CD206 antigen, which is a marker of inhibitory M2-type MΦs. Genes related to M2-type MUs were especially more highly expressed by CD45+CD206+ u-ADSCs than by CD45− u-ADSCs. CD45+ u-ADSCs inhibited the expression of cytokines/chemokines and suppressed the proliferation of splenocytes stimulated with ConA. We observed that not only whole u-ADSCs, but also the CD45+ subset of u-ADSCs ameliorated the ConA-induced hepatitis in mice. In conclusion, we show that freshly isolated murine u-ADSCs were effective against acute hepatitis, and CD45+ u-ADSCs acting phenotypically and functionally like M2-type MΦs, contributed to the repair of liver tissue undergoing inflammation. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim","subitem_description_type":"Abstract"}]},"item_4_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Embargo Period 12 months","subitem_description_type":"Other"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050487","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1002/eji.201646835","subitem_relation_type_select":"DOI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © Wiley"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00639610","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0014-2980","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nasti, Alessandro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakai, Yoshio"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Seki, Akihiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Buffa, Geraldine Belen"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Komura, Takuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mochida, Hatsune"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamato, Masatoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshida, Keiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ho, Tuyen T. B."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takamura, Masayuki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Usui, Soichiro"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Wada, Takashi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Honda, Masao"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kaneko, Shuichi"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-12-02"}],"displaytype":"detail","filename":"ME-PR-KANEKO-S-2163.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KANEKO-S-2163.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44145/files/ME-PR-KANEKO-S-2163.pdf"},"version_id":"b11ffb11-501d-40d3-a6f3-8b3d7bad0850"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The CD45+ fraction in murine adipose tissue derived stromal cells harbors immune-inhibitory inflammatory cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The CD45+ fraction in murine adipose tissue derived stromal cells harbors immune-inhibitory inflammatory cells"}]},"item_type_id":"4","owner":"18","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-13"},"publish_date":"2018-04-13","publish_status":"0","recid":"44145","relation_version_is_last":true,"title":["The CD45+ fraction in murine adipose tissue derived stromal cells harbors immune-inhibitory inflammatory cells"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T17:35:39.001138+00:00"}