{"created":"2023-07-27T06:50:56.784728+00:00","id":44147,"links":{},"metadata":{"_buckets":{"deposit":"5c999dc0-f1eb-4f46-b051-48208a0bcc98"},"_deposit":{"created_by":18,"id":"44147","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44147"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044147","sets":["1132:1133:1134"]},"author_link":["22250","24842","74077","74073","74079","74081","74090","74087","74080","69858","74074","74093","74091","23109","74076","74088","74089","74078","74092","74072","74071","74075","22248","74084"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"7781","bibliographicPageStart":"7774","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"Oncotarget"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"五十嵐, 健太郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山本, 憲男"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"林, 克洋"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"三輪, 真嗣"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"土屋, 弘行"}],"nameIdentifiers":[{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Relapsed osteosarcoma is a recalcitrant tumor. A patient's cisplatinum (CDDP)- resistant relapsed osteosarcoma lung metastasis was previously established orthotopically in the distal femur of mice to establish a patient-derived orthotopic xenograft (PDOX) model. In the present study, the PDOX models were randomized into the following groups when tumor volume reached 100 mm3: G1, control without treatment; G2, CDDP (6 mg/kg, intraperitoneal (i.p.) injection, weekly, for 2 weeks); gemcitabine (GEM) (100 mg/kg, i.p., weekly, for 2 weeks) combined with docetaxel (DOC) (20 mg/kg, i.p., once); temozolomide (TEM) (25 mg/kg, p.o., daily, for 2 weeks) combined with irinotecan (IRN) (4 mg/kg i.p., daily for 2 weeks). Tumor size and body weight were measured with calipers and a digital balance twice a week. After 2 weeks, all treatments significantly inhibited tumor growth except CDDP compared to the untreated control: CDDP: p = 0.093; GEM+DOC: p = 0.0002, TEM+IRN: p < 0.0001. TEM combined with IRN was significantly more effective than either CDDP (p = 0.0001) or GEM combined with DOC (p = 0.0003) and significantly regressed the tumor volume compared to day 0 (p = 0.003). Thus the PDOX model precisely identified the combination of TEM-IRN that could regress the CDDP-resistant relapsed metastatic osteosarcoma PDOX. © Igarashi et al.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050489","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Impact Journals LLC"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.18632/oncotarget.22892","subitem_relation_type_select":"DOI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © Igarashi et al."}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1949-2553","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Igarashi, Kentaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawaguchi, Kei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kiyuna, Tasuku"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyake, Kentaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyake, Masuyo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Li, Yunfeng"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nelson, Scott D."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Dry, Sarah M."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Singh, Arun S."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Elliott, Irmina A."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Russell, Tara A."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Eckardt, Mark A."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Norio"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Hayashi, Katsuhiro"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Kimura, Hiroaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miwa, Shinji"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Tsuchiya, Hiroyuki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Eilber, Fritz C."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hoffman, Robert M."}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-04-13"}],"displaytype":"detail","filename":"ME-PR-IGARASHI-K-7774.pdf","filesize":[{"value":"2.5 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-IGARASHI-K-7774.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44147/files/ME-PR-IGARASHI-K-7774.pdf"},"version_id":"e2b62914-f271-416e-8b77-03d311d448ce"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Temozolomide combined with irinotecan regresses a cisplatinumresistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) precision-oncology mouse model","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Temozolomide combined with irinotecan regresses a cisplatinumresistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) precision-oncology mouse model"}]},"item_type_id":"4","owner":"18","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-13"},"publish_date":"2018-04-13","publish_status":"0","recid":"44147","relation_version_is_last":true,"title":["Temozolomide combined with irinotecan regresses a cisplatinumresistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) precision-oncology mouse model"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T17:35:36.571718+00:00"}