@article{oai:kanazawa-u.repo.nii.ac.jp:00044154, author = {坂井, 健二 and 山田, 正仁 and Muroishi, Toyoteru and Sakai, Kenji and Yanase, Daisuke and Ikeda, Yoshihisa and Machiya, Tomohiko and Kato-Motozaki, Yuko and Samuraki, Miharu and Yamada, Masahito}, journal = {Journal of Clinical Neuroscience}, month = {Feb}, note = {We report the case of a 57-year-old man with neuromyelitis optica spectrum disorder (NMOSD) presenting as acute eosinophilic encephalomyelitis. Magnetic resonance imaging revealed central nervous system lesions typical of NMOSD and anti-aquaporin-4 antibodies in the serum were identified; however, eosinophilia was evident in the cerebrospinal fluid (CSF) at the early stage of the disease. The number of eosinophils in the CSF decreased subsequently. Although activation of eosinophils is known to be an important factor in the development of NMOSD lesions, prominent eosinophilia in the CSF at the early stage of the disease has never been reported in patients with NMOSD. © 2017 Elsevier Ltd., Embargo Period 12 months, 金沢大学附属病院神経内科}, pages = {93--94}, title = {Serum anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder presenting as acute eosinophilic encephalomyelitis}, volume = {48}, year = {2018} }