@article{oai:kanazawa-u.repo.nii.ac.jp:00044168,
 author = {和田, 泰三 and 東馬, 智子 and 白橋, 徹志郎 and 谷内江, 昭宏 and Wada, Taizo and Toma, Tomoko and Miyazawa, Hanae and Koizumi, Eiko and Shirahashi, Tetsujiro and Matsuda, Yusuke and Yachie, Akihiro},
 issue = {4},
 journal = {Journal of Dermatology},
 month = {Apr},
 note = {Epstein-Barr virus (EBV)-associated T- or natural killer (NK)-cell lymphoproliferative disease (LPD) is a heterogeneous group of disorders characterized by chronic proliferation of EBV-infected lymphocytes. Patients may present with severe skin manifestations, including hypersensitivity to mosquito bites (HMB) and hydroa vacciniforme (HV)-like eruption, which are characterized by blister formation and necrotic ulceration. Skin biopsy specimens show inflammatory reactions comprising EBV-infected lymphocytes. However, blister fluids have not been fully assessed in patients with this disease. Blister fluids were collected from three patients with EBV-associated LPD: two with HMB and one with HV. Immunophenotyping of blister lymphocytes and measurement of tumor necrosis factor (TNF)-α in blister fluids were performed. The patients with HMB and HV exhibited markedly increased percentages of NK and γδ T cells, respectively, in both peripheral blood and blister fluids. These NK and γδ T cells strongly expressed the activation marker human leukocyte antigen-DR and were considered to be cellular targets of EBV infections. TNF-α was highly elevated in all blister fluids. Severe local skin reactions of EBV-associated LPD may be associated with infiltrating EBV-infected lymphocytes and a high TNF-α concentration in blister fluids. © 2018 Japanese Dermatological Association., Embargo Period 12 months, 金沢大学附属病院小児科},
 pages = {444--449},
 title = {Characterization of skin blister fluids from children with Epstein-Barr virus-associated lymphoproliferative disease},
 volume = {45},
 year = {2018}
}