{"created":"2023-07-27T06:50:57.741835+00:00","id":44168,"links":{},"metadata":{"_buckets":{"deposit":"818927c5-e8ef-4c4b-b714-aa79a1cb053d"},"_deposit":{"created_by":18,"id":"44168","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44168"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044168","sets":["1761:1762:1763"]},"author_link":["72680","2504","20436","2881","24001","74200","70651","45639","70652","72682","70655"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-04-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"449","bibliographicPageStart":"444","bibliographicVolumeNumber":"45","bibliographic_titles":[{"bibliographic_title":"Journal of Dermatology"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"和田, 泰三"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"東馬, 智子"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"白橋, 徹志郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"谷内江, 昭宏"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Epstein-Barr virus (EBV)-associated T- or natural killer (NK)-cell lymphoproliferative disease (LPD) is a heterogeneous group of disorders characterized by chronic proliferation of EBV-infected lymphocytes. Patients may present with severe skin manifestations, including hypersensitivity to mosquito bites (HMB) and hydroa vacciniforme (HV)-like eruption, which are characterized by blister formation and necrotic ulceration. Skin biopsy specimens show inflammatory reactions comprising EBV-infected lymphocytes. However, blister fluids have not been fully assessed in patients with this disease. Blister fluids were collected from three patients with EBV-associated LPD: two with HMB and one with HV. Immunophenotyping of blister lymphocytes and measurement of tumor necrosis factor (TNF)-α in blister fluids were performed. The patients with HMB and HV exhibited markedly increased percentages of NK and γδ T cells, respectively, in both peripheral blood and blister fluids. These NK and γδ T cells strongly expressed the activation marker human leukocyte antigen-DR and were considered to be cellular targets of EBV infections. TNF-α was highly elevated in all blister fluids. Severe local skin reactions of EBV-associated LPD may be associated with infiltrating EBV-infected lymphocytes and a high TNF-α concentration in blister fluids. © 2018 Japanese Dermatological Association.","subitem_description_type":"Abstract"}]},"item_4_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Embargo Period 12 months","subitem_description_type":"Other"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院小児科","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050510","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本皮膚科学会 = Japanese Dermatological Association / Blackwell Publishing Ltd"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/1346-8138.14226","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.dermatol.or.jp/modules/publication/index.php?content_id=3"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.dermatol.or.jp/modules/publication/index.php?content_id=3","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2018 Japanese Dermatological Association."}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00696658","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-2407","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Wada, Taizo"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Toma, Tomoko"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Miyazawa, Hanae"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koizumi, Eiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shirahashi, Tetsujiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuda, Yusuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yachie, Akihiro"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-03"}],"displaytype":"detail","filename":"HO-PR-WADA-T-2018.pdf","filesize":[{"value":"179.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-WADA-T-444.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44168/files/HO-PR-WADA-T-2018.pdf"},"version_id":"b91f7c74-4742-48b4-ad66-cc16309b8010"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Characterization of skin blister fluids from children with Epstein-Barr virus-associated lymphoproliferative disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Characterization of skin blister fluids from children with Epstein-Barr virus-associated lymphoproliferative disease"}]},"item_type_id":"4","owner":"18","path":["1763"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-07"},"publish_date":"2018-05-07","publish_status":"0","recid":"44168","relation_version_is_last":true,"title":["Characterization of skin blister fluids from children with Epstein-Barr virus-associated lymphoproliferative disease"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T17:32:05.423241+00:00"}