{"created":"2023-07-27T06:50:59.480356+00:00","id":44211,"links":{},"metadata":{"_buckets":{"deposit":"4b527e92-48e7-4292-aace-cd9722f0c4c5"},"_deposit":{"created_by":18,"id":"44211","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44211"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044211","sets":["2812:2813:2820"]},"author_link":["74346","74347"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-23","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2011-04-01 - 2014-03-31","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"PYNOD (NLR ファミリーに属する細胞質蛋白)の欠損マウスを作成し、主に免疫系におけるPYNODの役割を検討した。PYNOD欠損マウスの自然免疫応答に明確な異常は認められず、獲得免疫応答である遅延型過敏症応答に異常が認められた。しかし、皮膚経路で免疫したマウスの所属リンパ節は正常な抗原特異的インターフェロンγ産生能を示し、末梢組織に投与した抗原が所属リンパ節に到達し、エフェクターT細胞が生成されるプロセスは正常であることが示唆された。したがって、PYNOD欠損マウスの獲得免疫応答異常の原因は所属リンパ節のエフェクターT細胞が末梢組織へ移動する段階以降に存在することが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"In this study, we have investigated the physiological role of PYNOD (a cytoplasmic protein belonging to the NLR family), especially its role in the immune system using PYNOD-deficient mice. PYNOD-deficient mice exhibited a clear defect in the delayed type hypersensitivity that is a type of acquired immune responses, whereas we could find no apparent defect in innate immune responses in these mice. However, draining lymph node cells isolated from PYNOD-deficient mice that had been immunized through skin routes exhibited normal antigen-specific IFN-gamma production, suggesting that peripheral antigen was successfully delivered to draining lymph nodes and effecter T cells were normally generated in these mice. Thus, it is likely that the cause of the defect in the acquired immune system of PYNOD-deficient mice exist in a process of or after the migration of effecter T cells from draining lymph nodes to peripheral tissues.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23390092, 研究期間(年度):2011-04-01 - 2014-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「炎症抑制型NLR蛋白PYNODの生理的・病理的役割の解明」課題番号:23390092\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23390092/23390092seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050553","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学がん進展制御研究所"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70250090","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390092/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23390092/23390092seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-04-19"}],"displaytype":"detail","filename":"CA-PR-SUDA-T-kaken 2014-4p.pdf","filesize":[{"value":"98.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-SUDA-T-kaken 2014-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44211/files/CA-PR-SUDA-T-kaken 2014-4p.pdf"},"version_id":"64996d05-2a42-465a-89f8-009412265437"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"炎症抑制型NLR蛋白PYNODの生理的・病理的役割の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"炎症抑制型NLR蛋白PYNODの生理的・病理的役割の解明"},{"subitem_title":"Physiological and pathological roles of PYND, an anti-inflammatory NLR protein","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-19"},"publish_date":"2018-04-19","publish_status":"0","recid":"44211","relation_version_is_last":true,"title":["炎症抑制型NLR蛋白PYNODの生理的・病理的役割の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:22:00.784076+00:00"}