{"created":"2023-07-27T06:50:59.621680+00:00","id":44214,"links":{},"metadata":{"_buckets":{"deposit":"5459d3cb-59fb-432d-86fb-9358e63b63cb"},"_deposit":{"created_by":18,"id":"44214","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44214"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044214","sets":["2812:2813:2823"]},"author_link":["2674","74353"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05-23","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2008-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"発達期小脳の免疫組織染色を行い、JSAP1および活性型JNKは増殖を停止し顆粒前駆細胞で強く共発現していることを見出した。また、小脳顆粒前駆細胞の分化過程における足場タンパク質JSAP1の細胞膜移行とその役割を明らかにした。本研究成果は、哺乳類JNK経路の空間的制御に足場タンパク質JSAP1が関与することを示した最初の知見である。さらに、小脳初代培養系を用いた解析を行い、JSAP1-JNKシグナル伝達系は小脳顆粒前駆細胞のプログラムを増殖型から分化型に変換する役割を担っていることを見出した。","subitem_description_type":"Abstract"},{"subitem_description":"We performed immunohistochemical analysis and found that JSAP1, a scaffold protein for JNK signaling pathways, is expressed predominantly in the post-mitotic granule cell precursors (GCPs) of the inner external granular layer. We also showed that when stimulated by FGF receptor, JSAP1 translocates to the plasma membrane, where it recruits JNK and facilitates the activation of JNK, leading to the differentiation of cerebellar GCPs. Furthermore, we found that JSAP1-JNK signaling promotes the cell cycle exit and differentiation of cerebellar GCPs.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「足場タンパク質JSAP1による小脳顆粒前駆細胞の増殖・分化制御機構の解析」課題番号20500282\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20500282/20500282seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050556","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60200937","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20500282/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20500282/20500282seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-04-19"}],"displaytype":"detail","filename":"CA-PR-YOSHIOKA-K-kaken 2011-5p.pdf","filesize":[{"value":"589.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-YOSHIOKA-K-kaken 2011-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44214/files/CA-PR-YOSHIOKA-K-kaken 2011-5p.pdf"},"version_id":"57ac2006-30a4-4514-a48c-1b1dbe1defb1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"足場タンパク質JSAP1による小脳顆粒前駆細胞の増殖・分化制御機構の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"足場タンパク質JSAP1による小脳顆粒前駆細胞の増殖・分化制御機構の解析"},{"subitem_title":"Research of the scaffold protein JSAP1 during the differentiation of cerebellar granule cell precursors","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-19"},"publish_date":"2018-04-19","publish_status":"0","recid":"44214","relation_version_is_last":true,"title":["足場タンパク質JSAP1による小脳顆粒前駆細胞の増殖・分化制御機構の解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:18:09.922812+00:00"}