{"created":"2023-07-27T06:50:59.892925+00:00","id":44220,"links":{},"metadata":{"_buckets":{"deposit":"c9d007c9-6eb9-4b91-8c8c-fe5e7ca7b196"},"_deposit":{"created_by":18,"id":"44220","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44220"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044220","sets":["2812:2813:2822"]},"author_link":["73972","26701"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-04-04","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2009-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Oshima, Masanobu"}],"nameIdentifiers":[{"nameIdentifier":"26701","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40324610","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40324610"},{"nameIdentifier":"40324610","nameIdentifierScheme":"金沢大学研究者情報","nameIdentifierURI":"http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=40324610"},{"nameIdentifier":"40324610","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000040324610"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"TGF-βシグナル遮断とCOX-2/PGE_2経路の相互作用による、胃がん発生への関与を解析するための新規マウスモデル作製を試みた。TGF-β受容体遺伝子を条件付きに欠損させるため、胃粘膜で特異的にCreリコンビナーゼを発現するマウスを作製した。その結果、発現に使用したK19遺伝子プロモーターは発生初期に全身で一過性に発現することや、成熟マウスにおいては転写活性が極めて低いことなどが明らかとなり、K19以外のプロモーターの使用が必要であることがわかった。","subitem_description_type":"Abstract"},{"subitem_description":"To generate a novel mouse model in which TGF-βsignaling is blocked and COX-2/PGE_2 pathway is activated, we tried construction of transgenic mice expressing Cre in gastric epithelial cells using K19 gene promoter. However, we found that K19 promoter is active in whole body during embryogenesis and its expression efficiency is very low in adult stomach, indicating that other promoter than K19 is required for future construction of stomach specific Cre mice.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:21390118, 研究期間(年度):2009-2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「COX-2/PGE2経路と炎症反応による胃がん発生促進機序の研究」課題番号21390118\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21390118/21390118seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050562","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学がん進展制御研究所"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40324610","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390118/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21390118/21390118seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大島, 正伸"}],"nameIdentifiers":[{"nameIdentifier":"73972","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40324610","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40324610"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-04-19"}],"displaytype":"detail","filename":"CA-PR-OSHIMA-M-kaken 2012-5p.pdf","filesize":[{"value":"285.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-OSHIMA-M-kaken 2012-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44220/files/CA-PR-OSHIMA-M-kaken 2012-5p.pdf"},"version_id":"e3d66055-b24f-461f-9c99-f37ff4e518bd"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"COX-2/PGE2経路と炎症反応による胃がん発生促進機序の研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"COX-2/PGE2経路と炎症反応による胃がん発生促進機序の研究"},{"subitem_title":"Gastric tumorigenesis through cooperation of COX-2/PGE2 pathway and inflammatory responses","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-19"},"publish_date":"2018-04-19","publish_status":"0","recid":"44220","relation_version_is_last":true,"title":["COX-2/PGE2経路と炎症反応による胃がん発生促進機序の研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:59:06.316901+00:00"}