{"created":"2023-07-27T06:51:00.347932+00:00","id":44233,"links":{},"metadata":{"_buckets":{"deposit":"f54a591c-dc9d-43f3-a22a-ce03494dea6a"},"_deposit":{"created_by":18,"id":"44233","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44233"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044233","sets":["2812:2813:2820"]},"author_link":["74393","74392"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-30","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2011-2013","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"胃癌診療、とくにスキルス胃癌において、悪性腹水を伴う癌性腹膜炎は治療に難渋する最も予後不良な病態で、本病態に対する新たな治療法開発は喫緊の重要課題である。\n本研究では、ヒトスキルス胃癌細胞株を用い、HGFならびに受容体であるMETを主な標的に、in vitro, in vivoにおけるHGFによる活性誘導の有無・METインヒビターによるそれら活性誘導阻害効果について検討した。スキルス胃癌はマウスに悪性腹水伴うがん性腹膜炎を形成した。間質誘導性のHGFがMetを介して増殖・細胞内シグナル活性化が関与することが判明した。MET-TKIによる治療は、スキルス胃癌進展を制御する新規標的治療となりうる。","subitem_description_type":"Abstract"},{"subitem_description":"Scirrhous gastric cancer frequently develops into peritoneal carcinomatosis with malignant ascites. We investigated the role of the HGF/MET axis in peritoneal carcinomatosis in scirrhous cancer. Scirrhous cell lines produced peritoneal carcinomatosis with massive ascites after intraperitoneal injection in nude mice. Their proliferation was stimulated by exogenous HGF in vitro. MET-TKIs inhibited HGF-stimulated proliferation of scirrhous cells. Furthermore, MET-TKIs prolonged the survival of mice bearing established tumors by scirrhous cells. In clinical specimens, HGF was markedly produced by stromal fibroblasts in scirrous cancer. Our results strongly suggest that paracrine HGF-induced activation of MET-mediated signaling pathways plays an important role in the pathogenesis of peritoneal carcinomatosis in scirrhous gastric cancer.Thus, MET signaling pathway may be a potential therapeutic target for peritoneal carcinomatosis of gastric cancer, even without MET amplification.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23591921, 研究期間(年度):2011-2013","subitem_description_type":"Other"},{"subitem_description":"出典：「HGF/cMET axis とHB-EGF を標的とした胃癌標的治療法の開発」研究成果報告書　課題番号23591921\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23591921/23591921seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050575","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学がん進展制御研究所"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=90262592"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=90262592","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591921/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591921/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23591921/23591921seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23591921/23591921seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-04-19"}],"displaytype":"detail","filename":"CA-PR-YASUMOTO-K-kaken 2014-4p.pdf","filesize":[{"value":"175.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-YASUMOTO-K-kaken 2014-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44233/files/CA-PR-YASUMOTO-K-kaken 2014-4p.pdf"},"version_id":"355a51f2-c68d-447a-8c45-29044bce3a11"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"HGF/cMET axis とHB-EGF を標的とした胃癌標的治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"HGF/cMET axis とHB-EGF を標的とした胃癌標的治療法の開発"},{"subitem_title":"Novel target therapy for the HGF/cMET axis and HB-EGF in gastric cancer","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-20"},"publish_date":"2018-04-20","publish_status":"0","recid":"44233","relation_version_is_last":true,"title":["HGF/cMET axis とHB-EGF を標的とした胃癌標的治療法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:19:59.984645+00:00"}