{"created":"2023-07-27T06:51:00.569880+00:00","id":44241,"links":{},"metadata":{"_buckets":{"deposit":"4b99a24f-a398-462d-86ef-67649ff2a71c"},"_deposit":{"created_by":18,"id":"44241","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44241"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044241","sets":["2812:2813:2816"]},"author_link":["47653","74409"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-09-11","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2015-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"コアリプログラミングタンパク質が分解される過程において、これらがどのように認識され、しかるべき'場'にリクルートされるかは不明である。本研究では、RBとATMの相互作用が、リジンアセチルトランスフェラーゼ-3b（Kat3b）のリクルート、アセチル化したコアリプログラミングタンパク質Oct3 / 4、Sox2、Klf4、Nanongおよびc-Myc（OSKNM）の認識、ユビキチン化複合体への組み込みと、その後のプロテアソーム分解を介して、幹細胞様集団の多能性および自己再生能を抑制することを実証した。これらの知見は、再生医療、神経変性疾患および癌において重要な意味を有すると考えられる。","subitem_description_type":"Abstract"},{"subitem_description":"How the core reprogramming proteins are identified and recruited for degradation is unknown. Here, we demonstrate that functions of the retinoblastoma (RB) and the ataxia telangiectasia mutated (ATM) repress the pluripotency and self-renewal ability of the stem cell-like cells included in genetically modified mouse embryonic fibroblasts (MEFs) and A-T human adult fibroblasts (A-T HAFs) through acetylation-driven ubiquitination and subsequent proteasomal degradation of Oct3/4, Sox2, Klf4, Nanog and c-Myc (OSKNM) proteins. We discovered that RB recruits lysine acetyltransferase-3b (Kat3b) and inhibits the transcription of histone deacetylase-5 (Hdac5) whereas, ATM shuttles Hdac5 into the nucleus and serve as adaptor protein, which identify and assemble the acetylated-OSKNM proteins into ubiquitination complexes with the E3 ubiquitin ligase Uhrf1 or Fbxw7. These novel findings have important implications in regenerative medicine, neurodegenerative diseases and cancer.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K06834, 研究期間(年度):2015-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「Identification of global epigenetic alterations indispensable for malignant transformation and mediated by the RB-ATM pathway」課題番号15K06834\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K06834/15K06834seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050583","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50402839"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50402839","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K06834/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K06834/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K06834/15K06834seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K06834/15K06834seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-06"}],"displaytype":"detail","filename":"CA-PR-SHAMMA-AAA-kaken 2018-6p.pdf","filesize":[{"value":"242.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-SHAMMA-AAA-kaken 2018-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44241/files/CA-PR-SHAMMA-AAA-kaken 2018-6p.pdf"},"version_id":"d5fcf7d5-4b32-42a9-ad68-a2cdd1b0ad8c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"Identification of global epigenetic alterations indispensable for malignant transformation and mediated by the RB-ATM pathway","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Identification of global epigenetic alterations indispensable for malignant transformation and mediated by the RB-ATM pathway"},{"subitem_title":"Identification of global epigenetic alterations indispensable for malignant transformation and mediated by the RB-ATM pathway","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-06"},"publish_date":"2019-04-06","publish_status":"0","recid":"44241","relation_version_is_last":true,"title":["Identification of global epigenetic alterations indispensable for malignant transformation and mediated by the RB-ATM pathway"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:03:23.969572+00:00"}