{"created":"2023-07-27T06:51:00.614173+00:00","id":44242,"links":{},"metadata":{"_buckets":{"deposit":"e68f3e88-6d7f-43a2-9b83-1f6a58309941"},"_deposit":{"created_by":18,"id":"44242","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44242"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044242","sets":["2812:2813:2821"]},"author_link":["47653","74409"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-27","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2010-2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"がん抑制遺伝子RBは多くのクロマチン修飾因子と結合し、その機能を制御する。このようなRBによるエピジェネティック制御機能を解明するために、我々はRB欠損モデルマウスとヒト原発がん組織を使い、RBとATMの相互作用がDNAメチル化酵素DNMT1の安定性を制御すること、また、DNAマイクロアレイ解析から数百のがん関連遺伝子のDNAメチル化状態が、RB-ATM-DNMT1の相互作用により調節されていることを発見した。","subitem_description_type":"Abstract"},{"subitem_description":"The retinoblastoma tumor suppressor gene (RB) product has been implicated in epigenetic control of gene expression due to its ability to physically bind to and regulates many of chromatin modifying factors. To elucidate the mechanism of RBepigenetic function, we performed genetic and epigenetic analyses in an Rb-deficient mouse and human primary cancer tissues. Her e we report that the genetic interaction of Rb and ATM regulates DNMT1 protein stability, and microarray analysis indicated that RB-ATM-DNMT1 interaction controls the DNA methylation status in the promoter of hundreds of cancer related genes.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22500998, 研究期間(年度):2010-2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「がん幹細胞化におけるRb-Ras経路の研究」課題番号22500998\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22500998/22500998seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050584","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学がん進展制御研究所"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50402839"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50402839","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22500998/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22500998/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22500998/22500998seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22500998/22500998seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-04-19"}],"displaytype":"detail","filename":"CA-PR-SHAMMA-A-kaken 2013-4p.pdf","filesize":[{"value":"306.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-SHAMMA-A-kaken 2013-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44242/files/CA-PR-SHAMMA-A-kaken 2013-4p.pdf"},"version_id":"ec2763b0-45f3-4d15-87ea-ce3e3415e9b1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"がん幹細胞化におけるRb-Ras経路の研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"がん幹細胞化におけるRb-Ras経路の研究"},{"subitem_title":"The role of Rb-Ras pathway in cancer stem cells","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-20"},"publish_date":"2018-04-20","publish_status":"0","recid":"44242","relation_version_is_last":true,"title":["がん幹細胞化におけるRb-Ras経路の研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:41:44.220523+00:00"}