{"created":"2023-07-27T06:51:00.746632+00:00","id":44249,"links":{},"metadata":{"_buckets":{"deposit":"8bdb2f16-e528-4eaa-856c-8c6f43313d9c"},"_deposit":{"created_by":18,"id":"44249","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44249"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044249","sets":["2812:2813:2821"]},"author_link":["48163","74413"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-07","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2011-2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"多くの組織幹細胞が静止期に存在する状況において、細胞内ATP濃度の調節は幹細胞の寿命や振る舞いを制御する上で重要な因子として考えられる。本研究課題においてはエネルギーセンサーとして機能するLKB1-AMPKシグナルに着目し、LKB1およびAMPK欠損造血幹細胞について解析を行った。その結果、これらの分子は造血幹細胞の維持に寄与していることを明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"Many tissue specific stem cells stay dormant. Therefore, the regulation of intracellular ATP is important for the control of the longevity or behaviors of stem cells. The LKB1-AMPK signaling functions as an intracellular energy sensor. To examine the role of LKB1 or AMPK in the regulatory system of hematopoietic stem cell, I analyzed LKB1- or AMPK-deficient hematopoietic stem cells. Our data demonstrated that LKB1 and AMPK contributed to the maintenance of hematopoietic stem cells.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23791076, 研究期間(年度):2011-2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「細胞内ATP調節による造血幹細胞制御機構の解明」課題番号23791076\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23791076/23791076seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050591","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学がん進展制御研究所"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00447343"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00447343","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791076/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791076/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23791076/23791076seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23791076/23791076seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-04-19"}],"displaytype":"detail","filename":"CA-PR-TADOKORO-Y-kaken 2013-4p.pdf","filesize":[{"value":"350.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-TADOKORO-Y-kaken 2013-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44249/files/CA-PR-TADOKORO-Y-kaken 2013-4p.pdf"},"version_id":"29c6155a-8a04-4939-8629-adafaf3633ce"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"細胞内ATP調節による造血幹細胞制御機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"細胞内ATP調節による造血幹細胞制御機構の解明"},{"subitem_title":"Regulations of hematopoietic stem cell system by the control of intracellular ATP","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-20"},"publish_date":"2018-04-20","publish_status":"0","recid":"44249","relation_version_is_last":true,"title":["細胞内ATP調節による造血幹細胞制御機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:41:43.051190+00:00"}