{"created":"2023-07-27T06:51:00.791439+00:00","id":44250,"links":{},"metadata":{"_buckets":{"deposit":"a9625a97-2a90-4122-be2f-fb530f9aebdb"},"_deposit":{"created_by":18,"id":"44250","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44250"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044250","sets":["2812:2813:2823"]},"author_link":["85194","85192"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05-19","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2008-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究課題では、造血幹細胞と白血病幹細胞およびそれらのニッチについての相違点を理解することを目的としている。そのためにSpred-1ノックアウト造血幹細胞および白血病発症モデルマウスを用いて競合的骨髄移植法による解析を行なった。その結果、造血幹細胞と白血病幹細胞はよく似た表面マーカー・多分化能を示し、また一時的にニッチにおいて競合していることが示唆された。しかし、有意差を持って白血病発症マウスをレスキューすることはできなかった。","subitem_description_type":"Abstract"},{"subitem_description":"The aim of this research project is to understand both the similarities and differences between hematopoietic stem cells and leukemic stem cells and their niches. I have carried out competitive repopulation assay using Spred-1 knockout and leukemia-developed mouse bone marrow cells. Leukemic stem cells showed cell surface marker phenotype and multipotency similar to that of hematopoietic stem cells. Furthermore, competitive repopulation assay with Spred-1 knockout bone marrow cells suggested that both stem cells might compete in their sharing niches. However, Spred-1 knockout cells could not significantly rescue the leukemia-developed mice.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「Spred-1の機能に着目した造血幹細胞及び白血病幹細胞ニッチの解析」課題番号21790910\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21790910/21790910seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050592","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00447343"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00447343","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790910/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790910/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21790910/21790910seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21790910/21790910seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-04-19"}],"displaytype":"detail","filename":"CA-PR-TADOKORO-Y-kaken 2011-5p.pdf","filesize":[{"value":"185.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-TADOKORO-Y-kaken 2011-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44250/files/CA-PR-TADOKORO-Y-kaken 2011-5p.pdf"},"version_id":"28b07de9-3fec-4953-b7c4-0e463f06b2e0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"Spred-1の機能に着目した造血幹細胞及び白血病幹細胞ニッチの解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Spred-1の機能に着目した造血幹細胞及び白血病幹細胞ニッチの解析"},{"subitem_title":"Analysis of hematopoietic stem cell and leukemic stem cell niche by focusing on Spred-1 functions","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-20"},"publish_date":"2018-04-20","publish_status":"0","recid":"44250","relation_version_is_last":true,"title":["Spred-1の機能に着目した造血幹細胞及び白血病幹細胞ニッチの解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:18:06.868592+00:00"}