@article{oai:kanazawa-u.repo.nii.ac.jp:00044256,
 author = {原, 章規 and 古市, 賢吾 and 岩田, 恭宜 and 坂井, 宣彦 and 清水, 美保 and 金子, 周一 and 中村, 裕之 and 和田, 隆志 and Hara, Akinori and Furuichi, Kengo and Koshino, Akihiko and Yasuda, Haruka and Tran, Trang Thi Thu and Iwata, Yasunori and Sakai, Norihiko and Shimizu, Miho and Kaneko, Shuichi and Nakamura, Hiroyuki and Wada, Takashi},
 issue = {1},
 journal = {Kidney International Reports},
 month = {Jan},
 note = {Introduction: We examined the impact of autoantibodies on the erythropoietin receptor (EPOR) in type 2 diabetic patients with chronic kidney disease (CKD). Methods: A total of 112 Japanese patients with type 2 diabetes who had CKD were enrolled in this study and followed for a mean of 45 months. Sera from these patients were screened for anti-EPOR antibodies using enzyme-linked immunosorbent assays. Results: Anti-EPOR antibodies were detected in 26 patients (23%). Anti-EPOR antibodies were associated with low hemoglobin concentrations and decreased renal function. In patients with biopsy-proven diabetic nephropathy, anti-EPOR antibodies were associated with increased levels of interstitial inflammation. A decrease in renal function was observed more frequently in patients with antibodies than in those without antibodies, and the presence of the antibodies together with well-known clinical parameters, including proteinuria and low glomerular filtration rate, was a significant risk factor for end-stage renal disease. In human tubular epithelial HK-2 cells, IgG fractions containing anti-EPOR antibodies upregulated the expression of monocyte chemoattractant protein-1 mRNA under a high concentration of glucose. Conclusion: Anti-EPOR antibodies might be involved in the progression of renal lesions and in the impaired erythropoiesis in type 2 diabetic patients with CKD. Furthermore, the presence of anti-EPOR antibodies may be an additional predictor for end-stage renal disease in type 2 diabetes. © 2017 International Society of Nephrology, Embargo Period 12 months, 金沢大学医薬保健研究域医学系},
 pages = {133--141},
 title = {Clinical and Pathological Significance of Autoantibodies to Erythropoietin Receptor in Type 2 Diabetic Patients With CKD},
 volume = {3},
 year = {2018}
}