{"created":"2023-07-27T06:51:01.862541+00:00","id":44275,"links":{},"metadata":{"_buckets":{"deposit":"10e665b0-a109-48ea-9f23-542836b55ee8"},"_deposit":{"created_by":18,"id":"44275","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44275"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044275","sets":["2812:2813:2819"]},"author_link":["21326","70654"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-12","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2012-04-01 - 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Wada, Taizo"}],"nameIdentifiers":[{"nameIdentifier":"21326","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30313646","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30313646"},{"nameIdentifier":"30313646","nameIdentifierScheme":"金沢大学研究者情報","nameIdentifierURI":"http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=30313646"},{"nameIdentifier":"30313646","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000030313646"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"EBウイルス関連血球貪食性リンパ組織球症（EBV-HLH）は、EBVのCD8+ T細胞への異所性感染とそのモノクローナルな増殖により引き起こされる。我々は、EBV感染CD8陽性T細胞が特定のTCR Vβを有しCD5発現の低下した異常活性化細胞として同定可能であることを報告し、さらにサイトカインプロファイルの特徴を明らかにした。ただし活性化CD8陽性T細胞におけるCD5発現の低下自体はEBV-HLHに特異的ではないため、TCR Vβレパトア解析を併用し評価する必要がある。本研究により、これらの細胞解析とサイトカイン解析の併用はEBV-HLHの診断、病態把握に有用であることが明らかにされた。","subitem_description_type":"Abstract"},{"subitem_description":"Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH) is characterized by ectopic EBV infection in CD8+ T cells and their clonal proliferation. We demonstrate that EBV-infected cells can be detected as highly activated CD5-/dim CD8+ T cells that often react with a specific TCR Vβ monoclonal antibody in patients with EBV-HLH, who exhibit characteristic profiles of serum cytokines. Although down-regulation of CD5 in CD8+ T cells is not specific for EBV-HLH, the combined approach of our flow cytometric analysis including TCR Vβ repertoire and cytokine profile analysis may be useful in diagnosis and follow-up of patients with EBV-HLH.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24591542, 研究期間(年度):2012-04-01 - 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「EBV関連血球貪食性リンパ組織球症におけるEBV感染Ｔ細胞の解析と病態解明」課題番号24591542\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24591542/24591542seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院小児科","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050617","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30313646"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30313646","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24591542/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24591542/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24591542/24591542seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24591542/24591542seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"和田, 泰三"}],"nameIdentifiers":[{"nameIdentifier":"70654","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30313646","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30313646"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-04-26"}],"displaytype":"detail","filename":"ME-PR-WADA-T-kaken 2015-5p.pdf","filesize":[{"value":"96.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-WADA-T-kaken 2015-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44275/files/ME-PR-WADA-T-kaken 2015-5p.pdf"},"version_id":"d6410bb6-1041-426a-8a93-ca7b275c1d6b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"EBV関連血球貪食性リンパ組織球症におけるEBV感染Ｔ細胞の解析と病態解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"EBV関連血球貪食性リンパ組織球症におけるEBV感染Ｔ細胞の解析と病態解明"},{"subitem_title":"Analysis of Epstein-Barr virus (EBV)-infected T cells in EBV associated hemophagocytic lymphohistiocytosis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-26"},"publish_date":"2018-04-26","publish_status":"0","recid":"44275","relation_version_is_last":true,"title":["EBV関連血球貪食性リンパ組織球症におけるEBV感染Ｔ細胞の解析と病態解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:47:16.145292+00:00"}