{"created":"2023-07-27T06:51:02.462414+00:00","id":44288,"links":{},"metadata":{"_buckets":{"deposit":"ffdefb6c-bed7-466e-866b-f17d65f0891b"},"_deposit":{"created_by":18,"id":"44288","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44288"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044288","sets":["2812:2813:2819"]},"author_link":["74055","93"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-21","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2012-04-01 - 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究はC型慢性肝炎におけるIFN応答・不応答の機序をIL28Bに注目して解析した。末梢血と肝組織のIFN誘導遺伝子（ISGs）発現解析から、IL28Bマイナーでは両者の発現の相関が消失し、肝臓での免疫担当細胞の減少が起こっていた。IL28Bマイナーではnon-canonical wntリガンドであるWnt5Aの発現亢進が認められ、Wnt5Aは肝細胞のISGsの誘導、ストレス顆粒蛋白G3BP1の発現誘導とHCV複製増強、さらにはケモカインの発現抑制を促し肝での免疫細胞浸潤の低下を誘導していると考えられた。IL28B・KOマウスの解析から、IL28Bと肝細胞浸潤との直接的な関連が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"The aim of this study is to investigate how IL28B is involved in the IFN resistance in patients of chronic hepatitis C. Comparison of gene expression profiling in PBMC and liver showed that the loss of correlation of ISGs expression between PBMC and liver in IL28B minor patients. Laser capture micro dissection analysis (LCM) of hepatocyte and liver infiltrated lymphocytes combined with immune-staining of surface marker of immune cells showed that infiltration of lymphocyte into the liver was impaired in patients with IL28B minor patients. Interestingly, non-canonical wnt ligand, WNT5A was up-regulated in the liver of IL28B minor patients and WNT5A induced ISGs and stress granule protein G3BP1, and increased HCV replication. WN5A repressed the expression of chemokines and play roles in the impairment of lymphocytes infiltration in liver. The analysis of newly developed IL28B knockout mouse showed that IL28B was directly involved in the lymphocytes infiltration in liver.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24390187, 研究期間(年度):2012-04-01 - 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「C型慢性肝炎治療成績の向上と肝発癌阻止を目指した分子基盤の確立」課題番号24390187\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24390187/24390187seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域保健学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050630","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00272980"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00272980","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24390187/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24390187/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24390187/24390187seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24390187/24390187seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-04-26"}],"displaytype":"detail","filename":"ME-PR-HONDA-M-kaken 2015-6p.pdf","filesize":[{"value":"435.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-HONDA-M-kaken 2015-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44288/files/ME-PR-HONDA-M-kaken 2015-6p.pdf"},"version_id":"f0994a53-6097-4b52-b973-e27e876db746"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"C型慢性肝炎治療成績の向上と肝発癌阻止を目指した分子基盤の確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"C型慢性肝炎治療成績の向上と肝発癌阻止を目指した分子基盤の確立"},{"subitem_title":"Establishment of molecular basis for improving the treatment efficacy of chronic hepatitis C and preventing the occurrence of hepatocellular carcinoma.","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-26"},"publish_date":"2018-04-26","publish_status":"0","recid":"44288","relation_version_is_last":true,"title":["C型慢性肝炎治療成績の向上と肝発癌阻止を目指した分子基盤の確立"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:44:44.211036+00:00"}