@article{oai:kanazawa-u.repo.nii.ac.jp:00044296,
 author = {大家, 理恵 and 八木, 邦公 and 今野, 哲雄 and 川尻, 剛照 and 林, 研至 and 野原, 淳 and 稲津, 明広 and 山岸, 正和 and Oka, Rie and Yamada, Takayoshi and Nakanishi, Chiaki and Konno, Tetsuo and Kawashiri, Masa-aki and Hayashi, Kenshi and Nohara, Atsushi and Inazu, Akihiro and Yamagishi, Masakazu},
 issue = {6},
 journal = {Journal of Atherosclerosis and Thrombosis},
 month = {},
 note = {Aim: The commonly observed relationship between increased visceral adiposity and metabolic abnormalities may be partly mediated by a concomitant increase in liver fat content. We evaluated the independent association between the level of alanine aminotransferase (ALT) as a surrogate marker of the liver fat content and the incidence of metabolic abnormalities after adjusting for the amount of visceral adipose tissue (AT). Methods: The subjects included 1,118 Japanese individuals (44% women) who underwent computed tomography to assess the amount of visceral AT on medical checkups. Cross-sectional associations between the serum ALT, visceral AT and metabolic risk factors were examined. Results: The ALT level and visceral AT were found to show a significant correlation (r =0.41 in men and r =0.36 in women, p<0.001). In a multivariable linear regression analysis, the ALT level and visceral AT were found to be independently associated with blood pressure in men and triglycerides and 2-hour post-challenge glucose in both genders (p<0.01), whereas only visceral AT was found to be associated with HDL-cholesterol (p<0.01). When the participants were classified into four subgroups based on the 75th percentiles of ALT and visceral AT, the low-ALT/high-visceral AT group, but not the high-ALT/low-visceral AT group, had a significantly higher odds ratio for low HDL-cholesterol among both genders (p<0.05) and for hypertriglyceridemia in men only (p<0.05). Meanwhile, the high-ALT/low-visceral AT group, but not the low-ALT/high-visceral AT group, had a significantly higher odds ratio for IGT among women (p<0.05). Conclusions: Although the ALT level and visceral AT were found to be independently associated with most metabolic risk factors, visceral AT had a dominant association with dyslipidemia in both genders, while the ALT level appeared to have a closer association with IGT in women., 出版者照会後に全文公開, 金沢大学医薬保健研究域医学系},
 pages = {582--592},
 title = {Relationships between alanine aminotransferase (ALT), visceral adipose tissue (AT) and metabolic risk factors in a middle-aged Japanese population},
 volume = {21},
 year = {2014}
}