{"created":"2023-07-27T06:51:02.821793+00:00","id":44296,"links":{},"metadata":{"_buckets":{"deposit":"38b13b67-a851-417b-857a-128421ead95f"},"_deposit":{"created_by":18,"id":"44296","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44296"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044296","sets":["1132:1133:1134"]},"author_link":["72542","266","342","30570","438","63343","781","265","2478","63344","69602","63330","21336","20207","21527","72722","333"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"592","bibliographicPageStart":"582","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"Journal of Atherosclerosis and Thrombosis"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大家, 理恵"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"八木, 邦公"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"今野, 哲雄"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"川尻, 剛照"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"林, 研至"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"野原, 淳"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"稲津, 明広"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"山岸, 正和"}],"nameIdentifiers":[{},{},{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aim: The commonly observed relationship between increased visceral adiposity and metabolic abnormalities may be partly mediated by a concomitant increase in liver fat content. We evaluated the independent association between the level of alanine aminotransferase (ALT) as a surrogate marker of the liver fat content and the incidence of metabolic abnormalities after adjusting for the amount of visceral adipose tissue (AT). Methods: The subjects included 1,118 Japanese individuals (44% women) who underwent computed tomography to assess the amount of visceral AT on medical checkups. Cross-sectional associations between the serum ALT, visceral AT and metabolic risk factors were examined. Results: The ALT level and visceral AT were found to show a significant correlation (r =0.41 in men and r =0.36 in women, p<0.001). In a multivariable linear regression analysis, the ALT level and visceral AT were found to be independently associated with blood pressure in men and triglycerides and 2-hour post-challenge glucose in both genders (p<0.01), whereas only visceral AT was found to be associated with HDL-cholesterol (p<0.01). When the participants were classified into four subgroups based on the 75th percentiles of ALT and visceral AT, the low-ALT/high-visceral AT group, but not the high-ALT/low-visceral AT group, had a significantly higher odds ratio for low HDL-cholesterol among both genders (p<0.05) and for hypertriglyceridemia in men only (p<0.05). Meanwhile, the high-ALT/low-visceral AT group, but not the low-ALT/high-visceral AT group, had a significantly higher odds ratio for IGT among women (p<0.05). Conclusions: Although the ALT level and visceral AT were found to be independently associated with most metabolic risk factors, visceral AT had a dominant association with dyslipidemia in both genders, while the ALT level appeared to have a closer association with IGT in women.","subitem_description_type":"Abstract"}]},"item_4_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出版者照会後に全文公開","subitem_description_type":"Other"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050638","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japan Atherosclerosis Society = 日本動脈硬化学会"}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.jstage.jst.go.jp/browse/jat/-char/en"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jstage.jst.go.jp/browse/jat/-char/en","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.j-athero.org/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.j-athero.org/","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © Japan Atherosclerosis Society 日本動脈硬化学会"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11018976","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1340-3478","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Oka, Rie"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Yamada, Takayoshi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Nakanishi, Chiaki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Konno, Tetsuo"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Kawashiri, Masa-aki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Hayashi, Kenshi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Nohara, Atsushi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Inazu, Akihiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Yamagishi, Masakazu"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-10"}],"displaytype":"detail","filename":"ME-PR-YAMAGISHI-M-582.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-YAMAGISHI-M-582.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44296/files/ME-PR-YAMAGISHI-M-582.pdf"},"version_id":"3de0d096-6f9c-4971-aa1b-7085e062c3fc"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Relationships between alanine aminotransferase (ALT), visceral adipose tissue (AT) and metabolic risk factors in a middle-aged Japanese population","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Relationships between alanine aminotransferase (ALT), visceral adipose tissue (AT) and metabolic risk factors in a middle-aged Japanese population"}]},"item_type_id":"4","owner":"18","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-10"},"publish_date":"2018-05-10","publish_status":"0","recid":"44296","relation_version_is_last":true,"title":["Relationships between alanine aminotransferase (ALT), visceral adipose tissue (AT) and metabolic risk factors in a middle-aged Japanese population"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T17:31:33.842304+00:00"}