| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-05-18 |
| タイトル |
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タイトル |
Fragmented QRS predicts heart failure progression in patients with hypertrophic cardiomyopathy |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| ID登録 |
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ID登録 |
10.24517/00050641 |
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ID登録タイプ |
JaLC |
| 著者 |
Nomura, Akihiro
Konno, Tetsuo
Fujita, Takashi
Tanaka, Yoshihiro
Nagata, Yoji
Tsuda, Toyonobu
Hodatsu, Akihiko
Sakata, Kenji
Nakamura, Hiroyuki
Kawashiri, Masa-aki
Fujino, Noboru
Yamagishi, Masakazu
Hayashi, Kenshi
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| 著者別表示 |
今野, 哲雄
坂田, 憲治
川尻, 剛照
藤野, 陽
山岸, 正和
林, 研至
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| 提供者所属 |
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内容記述タイプ |
Other |
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内容記述 |
金沢大学医薬保健研究域医学系 |
| 書誌情報 |
Circulation Journal
巻 79,
号 1,
p. 136-143,
発行日 2014-12-19
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1346-9843 |
| NCID |
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識別子タイプ |
NCID |
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関連識別子 |
BA81861067 |
| 出版者 |
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出版者 |
Japanese Circulation Society = 日本循環器学会 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background: Although fragmented QRS complex (frag-QRS) reflecting intra-ventricular conduction delay has been shown to be a prognostic marker for cardiac events, few data exist regarding the impact of frag-QRS on cardiac events in hypertrophic cardiomyopathy (HCM).Methods and Results: Ninety-four HCM patients (56 male; mean age, 58}17 years) were retrospectively investigated. Frag-QRS was defined as the presence of various RsR’ patterns in at least 2 contiguous ECG leads. Major arrhythmic events (MAE) were defined as sudden cardiac death, and combined sustained ventricular tachycardia/ventricular fibrillation. New-onset atrial fibrillation (AF) was diagnosed based on ECG during provisional or routine medical examination. Heart failure (HF) with hospitalization was defined as hospital admission due to subjective or objective symptoms. Frag-QRS was detected in 31 patients (33%). TNNI3 was the most frequent disease-causing gene. Median follow-up was 4.6 years. The 4-year cumulative survival rates of cardiac death, MAE, new-onset AF and HF with hospitalization were 97.6%, 94.6%, 87.5% and 89.3%, respectively. On multivariate analysis, frag-QRS was significantly associated with HF with hospitalization (adjusted hazard ratios [95% confidence intervals]: 5.4 [1.2–36], P=0.03). Moreover, HF-free survival was significantly lower in the frag-QRS (+) group compared to the frag-QRS (–) group (79.0% vs. 95.1%, P=0.03).Conclusions: Frag-QRS is associated with HF with hospitalization in HCM patients who had a unique distribution of gene mutations. © 2014, The Japanese Circulation Society |
| 内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
出版者照会後に全文公開 |
| 権利 |
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権利情報 |
Copyright © Japanese Circulation Society 日本循環器学会 |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連URI |
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識別子タイプ |
URI |
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関連識別子 |
http://www.j-circ.or.jp/ |
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関連名称 |
http://www.j-circ.or.jp/ |
| 関連URI |
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識別子タイプ |
URI |
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関連識別子 |
https://www.jstage.jst.go.jp/browse/circj/-char/en |
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関連名称 |
https://www.jstage.jst.go.jp/browse/circj/-char/en |
ME-PR-YAMAGISHI-M-136.pdf (826.4 kB)
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