@article{oai:kanazawa-u.repo.nii.ac.jp:00044301,
 author = {中西, 千明 and 今野, 哲雄 and 林, 研至 and 川尻, 剛照 and 山岸, 正和 and Nakanishi, Chiaki and Nagaya, Noritoshi and Ohnishi, Shunsuke and Yamahara, Kenichi and Takabatake, Shu and Konno, Tetsuo and Hayashi, Kenshi and Kawashiri, Masa-aki and Tsubokawa, Toshinari and Yamagishi, Masakazu},
 issue = {9},
 journal = {Circulation Journal},
 month = {Sep},
 note = {Background: Mesenchymal stem cells (MSC) are multipotent and reside in bone marrow (BM), adipose tissue and many other tissues. However, the molecular foundations underlying the differences in proliferation, differentiation potential and paracrine effects between adipose tissue-derived MSC (ASC) and BM-derived MSC (BM-MSC) are not well-known. Therefore, we investigated differences in the gene and secretory protein expressions of the 2 types of MSC. Methods and Results: ASC and BM-MSC were obtained from subcutaneous adipose tissue and BM of adult Lewis rats. ASC proliferated as rapidly as BM-MSC, and had expanded 200-fold in approximately 2 weeks. On microarray analysis of 31,099 genes, 571 (1.8%) were more highly (>3-fold) expressed in ASC, and a number of these genes were associated with mitosis and immune response. On the other hand, 571 genes (1.8%) were more highly expressed in BM-MSC, and some of these genes were associated with organ development and morphogenesis. In secretory protein analysis, ASC secreted significantly larger amounts of growth factor and inflammatory cytokines, such as vascular endothelial growth factor, hepatocyte growth factor and interleukin 6, whereas BM-MSC secreted significantly larger amounts of stromal-derived factor-1α. Conclusions: There are significant differences between ASC and BM-MSC in the cytokine secretome, which may provide clues to the molecule mechanisms associated with tissue regeneration and alternative cell sources., 出版者照会後に全文公開, 金沢大学医薬保健研究域医学系},
 pages = {2260--2268},
 title = {Gene and protein expression analysis of mesenchymal stem cells derived from rat adipose tissue and bone marrow},
 volume = {75},
 year = {2011}
}