{"created":"2023-07-27T06:51:04.582686+00:00","id":44337,"links":{},"metadata":{"_buckets":{"deposit":"b7c5a039-293f-4906-8b9e-82398afa47c8"},"_deposit":{"created_by":18,"id":"44337","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44337"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044337","sets":["2812:2813:2820"]},"author_link":["73848","79"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-23","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2011-2013","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ミセル化シスプラチンは、シスプラチンを内包したミセル化粒子として開発された。これは血中での安定性と癌細胞に特異的に集積するDrug Delivery Systemに基づく薬剤である。我々は、マウスモデルを用いて、ミセル化シスプラチンの頭頸部癌に対する有効性を検討し、従来のシスプラチンと同等の抗腫瘍効果を認め、さらに腎機能障害を軽減することを認めた。さらにミセル化シスプラチンのリンパ節転移制御能、リンパ移行性に関して検討し、従来のシスプラチンに比べてリンパ移行性が高く頸部リンパ節転移制御に有用であった。","subitem_description_type":"Abstract"},{"subitem_description":"Cisplatin (CDDP) has been a key drug for chemotherapy in patients with head and neck squamous cell carcinoma (HNSCC). Nephrotoxicity is one of its adverse reactions. To increase its antitumor effects and reduce such toxicity problems, polymeric micelles carrying CDDP (NC-6004) have been developed. This study was designed to evaluate the efficacy and safety of NC-6004. To investigate the antitumor and nephrotoxic effects of NC-6004, nude mice bearing OSC-19 were administered drugs. Both drugs showed equivalent antitumor effects. Mice with CDDP developed renal cell apoptosis; however, those injected with NC-6004 were almost free of renal cell injury. Moreover, in an orthotopic tongue cancer model, NC-6004 reduced the rate of lymph node metastasis to lower than that with CDDP. In conclusion, considering the potential advantages, NC-6004 represents a significant structural improvement in the development of a platinum complex.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23659792, 研究期間(年度):2011-2013","subitem_description_type":"Other"},{"subitem_description":"出典：「ミセル化シスプラチン開発による新規頭頸部癌治療コンセプト」研究成果報告書　課題番号23659792\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23659792/23659792seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050679","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70262582"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70262582","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659792/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659792/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23659792/23659792seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23659792/23659792seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-07"}],"displaytype":"detail","filename":"ME-PR-YOSHIZAKI-T-kaken 2014-4p.pdf","filesize":[{"value":"243.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-YOSHIZAKI-T-kaken 2014-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44337/files/ME-PR-YOSHIZAKI-T-kaken 2014-4p.pdf"},"version_id":"cb509f4d-6090-4428-81f0-3d544bf07f2d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ミセル化シスプラチン開発による新規頭頸部癌治療コンセプト","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ミセル化シスプラチン開発による新規頭頸部癌治療コンセプト"},{"subitem_title":"Tumor-targeted chemotherapy with the nanopolymer-based drug NC-6004 for oral squamous cell carcinoma","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-07"},"publish_date":"2018-05-07","publish_status":"0","recid":"44337","relation_version_is_last":true,"title":["ミセル化シスプラチン開発による新規頭頸部癌治療コンセプト"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:19:55.427680+00:00"}