{"created":"2023-07-27T06:51:04.676515+00:00","id":44339,"links":{},"metadata":{"_buckets":{"deposit":"c4aa5f94-842a-426a-8ed8-6a4fbe78c60a"},"_deposit":{"created_by":18,"id":"44339","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44339"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044339","sets":["2812:2813:2824"]},"author_link":["73848","79"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-04-26","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2006-2009","bibliographic_titles":[{"bibliographic_title":"平成21(2009)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2009 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ウイルス増殖活性化と癌化の関連について検討した。\n1)EBERsはプロテインキナーゼRを阻害して細胞増殖能を促進する\n2)ウイルス複製サイクル誘導により、細胞死に至る\n3)脱メチル化およびアセチル化、いずれの処理によってもLMP1、EBV複製は誘導されない\n4)ウイルス複製により脱メチルかがおこり、複製直後のEBV感染細胞内のLMP1発現は複製誘導前よりも増加する\n以上より、EBVLMP1発現は上咽頭がん発癌過程に密接に関与する。しかし、一度がん化した後はがん細胞に影響を及ぼさないことが示唆された。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18390456, 研究期間(年度):2006-2009","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「EBウイルス活性化による遺伝子発現変化と上咽頭組織がん化に関する研究」課題番号18390456\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18390456/18390456seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050681","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70262582"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70262582","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390456/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390456/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18390456/18390456seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18390456/18390456seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-10"}],"displaytype":"detail","filename":"ME-PR-YOSHIZAKI-T-kaken 2010-5p.pdf","filesize":[{"value":"176.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-YOSHIZAKI-T-kaken 2010-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44339/files/ME-PR-YOSHIZAKI-T-kaken 2010-5p.pdf"},"version_id":"247908f0-68da-497f-a83e-4ff3469112d4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"EBウイルス活性化による遺伝子発現変化と上咽頭組織がん化に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"EBウイルス活性化による遺伝子発現変化と上咽頭組織がん化に関する研究"},{"subitem_title":"EBV gene expression profile which is affected by virus reactivation and oncogenesis of nasopharyngeal carcinoma","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2824"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-10"},"publish_date":"2018-05-10","publish_status":"0","recid":"44339","relation_version_is_last":true,"title":["EBウイルス活性化による遺伝子発現変化と上咽頭組織がん化に関する研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:15:23.964235+00:00"}