{"created":"2023-07-27T06:51:05.304528+00:00","id":44353,"links":{},"metadata":{"_buckets":{"deposit":"71a922b1-75ee-4fa3-ba20-3fcd53849a11"},"_deposit":{"created_by":18,"id":"44353","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44353"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044353","sets":["2812:2813:2820"]},"author_link":["75499","143"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-23","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2011-2013","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"制御性B細胞はIL-10産生を介して過剰な免疫反応や炎症を抑制する。全身性強皮症のPBMC中のIL-10産生B細胞の頻度を解析しところ、健常人で平均11%、強皮症は6%と有意に減少していた。次に制御性B細胞が存在しないCD19欠損マウスを使用しサイトカイン誘導性線維化モデルマウスにおける産生制御性B細胞の機能解析をした。野生型マウスとCD19欠損マウスにサイトカイン誘導性線維化モデルを誘導したところ、両者間に有意差はなかった。以上より、制御性B細胞はサイトカイン誘導性線維化モデルマウスでその役割が少ないことから、線維化病態促進への関与は少なく、強皮症の発症に深く関与している可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Regulatory B cells that produce IL-10 are an important role for negative immune response. The frequency of regulatory B cell in PBMC from 28 systemic sclerosis patients and 24 healthy controls were examined. The frequency of regulatory B cell in PBMC was decreased in systemic sclerosis patients compared to healthy controls. Next, the role of regulatory B cell in the cytokine induced fibrosis models was examined using lack of regulatory B cell mice (CD19 deficient mice). There was no significant difference between wild type mice and CD19 deficient mice.These results suggest that decreased regulatory B cell may contribute to pathogenesis of systemic sclerosis, although regulatory B cell does not affect the development of fibrosis.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23591640, 研究期間(年度):2011-2013","subitem_description_type":"Other"},{"subitem_description":"出典：「全身性強皮症患者および線維化モデルマウスにおける制御性Ｂ細胞の解析」研究成果報告書　課題番号23591640\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23591640/23591640seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050695","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50142253"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50142253","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591640/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591640/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23591640/23591640seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23591640/23591640seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-11"}],"displaytype":"detail","filename":"ME-PR-TAKEHARA-K-kaken 2014-6p.pdf","filesize":[{"value":"586.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-TAKEHARA-K-kaken 2014-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44353/files/ME-PR-TAKEHARA-K-kaken 2014-6p.pdf"},"version_id":"c3f65dd6-b3dd-41c6-bf2c-021fdb5d6a28"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"全身性強皮症患者および線維化モデルマウスにおける制御性Ｂ細胞の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"全身性強皮症患者および線維化モデルマウスにおける制御性Ｂ細胞の解析"},{"subitem_title":"The role of regulatory B cell in systemic sclerosis and cytokine-induced fibrosis models","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-11"},"publish_date":"2018-05-11","publish_status":"0","recid":"44353","relation_version_is_last":true,"title":["全身性強皮症患者および線維化モデルマウスにおける制御性Ｂ細胞の解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T09:19:54.299264+00:00"}