{"created":"2023-07-27T06:51:05.707288+00:00","id":44362,"links":{},"metadata":{"_buckets":{"deposit":"66216236-22cf-4beb-b02a-b1ecbb02d00f"},"_deposit":{"created_by":18,"id":"44362","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44362"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044362","sets":["2812:2813:2817"]},"author_link":["75509","233"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-28","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2014-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"筋萎縮性側索硬化症(ALS)における小胞体ストレス応答(UPR)の重要性を明らかにする為、UPRのセンサーATF6αを欠損したATF6(-/-)マウスとALSマウスを交配し、表現型の変化を観察した。その結果、ATF6(-/-)×ALSマウスではALSマウスに比べてALS発症時期が有意に早まったが、生存期間については両者で差は認められなかった。更に、前者では後者に比べてより早期から運動神経線維に変異蛋白質の集積を認める一方、ATF6欠損によりミクログリアを介した脳内炎症は減弱することが明らかになった。以上より、時期、細胞特異的なATF6の発現調節がALSの病態制御に重要であることが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"To dissect the role of the unfolded protein response (UPR) in the pathology of amyotrophic lateral sclerosis (ALS), we crossed ALS (SOD G93A Tg) mice with Atf6α-/- mice, the latter of which lack ATF6a, a major sensor in the UPR. Analysis using ALS and ALS/Atf6α-/- mice revealed the onset time of ALS was significantly earlier in ALS/Atf6α-/- mice, but the life span was not significantly different between two genotypes. Consistent with these results, higher levels of SOD aggregation was observed in ALS/Atf6α-/- mice before the onset, while lower levels of activation was observed in Atf6α-/- mouse-derived microglia, compared with wild-type mouse-derived microglia. These results suggest the time- and cell type-specific regulation of ATF6 may play the important role in the pathology of ALS.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26430069, 研究期間(年度):2014-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「ATF6ノックアウトマウスを用いたALSの病態解明」研究成果報告書　課題番号26430069\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26430069/26430069seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050704","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60303947"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60303947","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26430069/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26430069/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26430069/26430069seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26430069/26430069seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-11"}],"displaytype":"detail","filename":"ME-PR-HORI-O-kaken 2017-5p.pdf","filesize":[{"value":"887.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-HORI-O-kaken 2017-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44362/files/ME-PR-HORI-O-kaken 2017-5p.pdf"},"version_id":"9fc6f456-3ba1-4f97-bbb3-ad8e3c167cfc"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ATF6ノックアウトマウスを用いたALSの病態解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ATF6ノックアウトマウスを用いたALSの病態解明"},{"subitem_title":"The effect of ATF6 deletion on ALS pathology","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-11"},"publish_date":"2018-05-11","publish_status":"0","recid":"44362","relation_version_is_last":true,"title":["ATF6ノックアウトマウスを用いたALSの病態解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:36:16.960755+00:00"}