{"created":"2023-07-27T06:51:05.797085+00:00","id":44364,"links":{},"metadata":{"_buckets":{"deposit":"b04e20ea-aff6-486c-b82a-aa27b2c26868"},"_deposit":{"created_by":18,"id":"44364","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44364"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044364","sets":["2812:2813:2825"]},"author_link":["75509","233"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-05-07","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2007-2008","bibliographic_titles":[{"bibliographic_title":"平成20(2008)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2008 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"神経系細胞株PC12をBSOで処理すると、(1)細胞内グルタチオンの枯渇、(2)小胞体内での酸化ストレス発生、そして(3)細胞死が誘導された。この時、細胞を小胞体ストレス誘導剤ツニカマイシンで処理すると細胞死は増加し、逆に小胞体ストレス制御物質で処理すると減少した。マウスパーキンソン病(PD)モデルにおいても、(1)細胞内グルタチオンの低下、(2)小胞体ストレスの増加、(3)神経細胞死が認められた事から、グルタチオン枯渇により誘導される小胞体ストレス由来神経細胞死の重要性が示唆された。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:19500319, 研究期間(年度):2007-2008","subitem_description_type":"Other"},{"subitem_description":"出典：「小胞体内レドックス異常により誘導される神経細胞死とその制御」研究成果報告書　課題番号19500319\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19500319/19500319seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050706","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60303947"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60303947","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19500319/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19500319/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19500319/19500319seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19500319/19500319seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-11"}],"displaytype":"detail","filename":"ME-PR-HORI-O-kaken 2009-4p.pdf","filesize":[{"value":"244.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-HORI-O-kaken 2009-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44364/files/ME-PR-HORI-O-kaken 2009-4p.pdf"},"version_id":"2b337151-3c17-4a15-89e8-feee30154e62"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"小胞体内レドックス異常により誘導される神経細胞死とその制御","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"小胞体内レドックス異常により誘導される神経細胞死とその制御"},{"subitem_title":"Prevention of neuronal cell death associated with altered redox in the endoplasmic reticulum (ER)","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2825"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-11"},"publish_date":"2018-05-11","publish_status":"0","recid":"44364","relation_version_is_last":true,"title":["小胞体内レドックス異常により誘導される神経細胞死とその制御"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:15:09.084007+00:00"}