{"created":"2023-07-27T06:51:05.974854+00:00","id":44368,"links":{},"metadata":{"_buckets":{"deposit":"e59927ef-e569-49a2-85b8-bf1ee8edb905"},"_deposit":{"created_by":18,"id":"44368","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44368"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044368","sets":["2812:2813:2817"]},"author_link":["47"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-12","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2013-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"嗜好食品にはカフェイン、テオフィリンやテオブロミンなどのメチルキサンチン誘導体を成分にもつ食品が数多くある。本研究では、カカオ多くに含まれるメチルキサンチン誘導体、テオブロミンの生体へ与える影響を動物や細胞を用いて検討した。\nテオブロミン刺激により（悪性度の高い）神経膠芽腫細胞において細胞死を誘導するシグナルの活性化、および細胞増殖に関与するシグナルの抑制が観察された。一方、マウスの行動性学習能力がテオブロミン入り飼料の摂取により促進することが明らかとなった。また、脳内では脳機能促進を司る脳由来神経栄養因子の上昇が観察された。","subitem_description_type":"Abstract"},{"subitem_description":"Theobromine, which is a caffeine derivative, is the primary methylxanthine produced by Theobroma cacao. Mice were fed a diet supplemented with 0.05% theobromine for 30 days. The theobromine-fed (TB) mice performed better on the three-lever task than the control (CN) mice did. Brain-derived neurotrophic factor (BDNF) in brain were higher in the TB mice compared with those in the CN mice. BDNF supports cell survival and neuronal functions, including learning and memory. These results strongly suggested that orally administered theobromine augmented the motor learning in mice.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25282021, 研究期間(年度):2013-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「嗜好食品ががん化、老化、発達障害を予防する: メチルキサンチン誘導体を中心として」研究成果報告書　課題番号25282021\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25282021/25282021seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050710","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80272954"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80272954","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25282021/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25282021/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25282021/25282021seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25282021/25282021seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-14"}],"displaytype":"detail","filename":"ME-PR-SUGIMOTO-N-kaken 2017-5p.pdf","filesize":[{"value":"424.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SUGIMOTO-N-kaken 2017-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44368/files/ME-PR-SUGIMOTO-N-kaken 2017-5p.pdf"},"version_id":"9fc98f6d-7818-436c-ad15-51150d94e764"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"嗜好食品ががん化、老化、発達障害を予防する: メチルキサンチン誘導体を中心として","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"嗜好食品ががん化、老化、発達障害を予防する: メチルキサンチン誘導体を中心として"},{"subitem_title":"The roles methylxanthine derivative on prevention of several disorders","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-14"},"publish_date":"2018-05-14","publish_status":"0","recid":"44368","relation_version_is_last":true,"title":["嗜好食品ががん化、老化、発達障害を予防する: メチルキサンチン誘導体を中心として"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:36:15.099391+00:00"}