{"created":"2023-07-27T06:51:06.288176+00:00","id":44375,"links":{},"metadata":{"_buckets":{"deposit":"977dbdb3-b9f6-4602-a391-b65694cd8f03"},"_deposit":{"created_by":18,"id":"44375","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44375"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044375","sets":["2812:2813:2821"]},"author_link":["23919","55"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2011-2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ホスファチジルイノシトール(phosphatidylinositol; PI) 3-キナーゼ(PI3K) クラスIIα型酵素PI3K-C2αは、血管内皮細胞において経小胞輸送に必須の役割をはたす。PI3K-C2αノックアウトマウスでは、アナフィラキシーメディエーター投与後の血管透過性亢進が著しく増強し、アンジオテンシンII の投与により解離性大動脈瘤が高頻度に生じた。PI3K-C2αはクラスI PI3Kとは異なる独自の機構により血管バリア機能制御に必須であり、血管病に対する新しい治療標的となる可能性が示唆される。","subitem_description_type":"Abstract"},{"subitem_description":"Class II α isoform of phosphatidylinositol 3-kinase (PI3K-C2α) plays the essential role for vesicular trafficking in vascular endothelial cells. In PI3K-C2α-deleted mice, vascular permeability increase after administration of edematogenic mediator was exaggerated compared with wild-type mice. PI3K-C2α-deleted mice also showed a higher frequency of the formation of dissecting aortic aneurysms. Thus, PI3K-C2α is crucial for maintaining vascular integrity through the distinct action from that of class I PI3K, and suggested to be a potential useful therapeutic target for vascular diseases.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23659170, 研究期間(年度):2011-2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「PI3KクラスIIα酵素欠損マウスにおける血管健常性の破綻」課題番号23659170\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23659170/23659170seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050717","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60171592"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60171592","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659170/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659170/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23659170/23659170seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23659170/23659170seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-14"}],"displaytype":"detail","filename":"ME-PR-TAKUWA-Y-kaken 2013-4p.pdf","filesize":[{"value":"355.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-TAKUWA-Y-kaken 2013-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44375/files/ME-PR-TAKUWA-Y-kaken 2013-4p.pdf"},"version_id":"d1e32241-344a-4745-abc3-16a443aebf51"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"PI3KクラスIIα酵素欠損マウスにおける血管健常性の破綻","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PI3KクラスIIα酵素欠損マウスにおける血管健常性の破綻"},{"subitem_title":"Disruption of vascular integrity by deficiency of PI3K class II α isoform in mice","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-14"},"publish_date":"2018-05-14","publish_status":"0","recid":"44375","relation_version_is_last":true,"title":["PI3KクラスIIα酵素欠損マウスにおける血管健常性の破綻"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:41:39.793688+00:00"}