{"created":"2023-07-27T06:51:06.332767+00:00","id":44376,"links":{},"metadata":{"_buckets":{"deposit":"3f890a45-a32c-4967-a9b9-2f620139e194"},"_deposit":{"created_by":18,"id":"44376","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44376"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044376","sets":["2812:2813:2822"]},"author_link":["23919","55"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-18","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2009-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"S1Pは、内皮細胞・骨髄由来細胞のS1P2などを介して腫瘍血管新生などの血管形成を制御し、マクロファージのS1P2を介して粥状動脈硬化を促進し、さらに複数の受容体を介して血管バリア機能を調節する。また、心臓では、線維化や肥大といったリモデリングに関与する。ホスファチジルイノシトールを産生するPI3Kの2型受容体が新しい機構で血管新生に関与することを見出した。これらの結果は機能性脂質が新規な治療標的となることを示唆する。","subitem_description_type":"Abstract"},{"subitem_description":"The lysophospholipid mediator sphingosine-1-phosphate(S1P) exerts a facilitative effect on atherosclerosis via S1P2 receptor in macrophages, regulatory effects on angiogenesis including tumor angiogenesis via multiple receptors, and modulatory effects on vascular barrier function. S1P also is involved in cardiac remodeling. Phosphatidylinositol 3-kinase class II, which produces phosphatidylinositol 3-phosphate, plays the crucial role in angiogenesis through a novel mechanism. These observations suggest the possibility that the functional lipids S1P and phosphatidylinositol 3-phosphate could be potential novel therapeutic targets for cardiovascular diseases.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:21390057, 研究期間(年度):2009-2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「心血管ホメオスターシスとその破綻における機能性脂質の役割」課題番号21390057\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21390057/21390057seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050718","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=60171592"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=60171592","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390057/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390057/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21390057/21390057seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21390057/21390057seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-14"}],"displaytype":"detail","filename":"ME-PR-TAKUWA-Y-kaken 2012-6p.pdf","filesize":[{"value":"289.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-TAKUWA-Y-kaken 2012-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44376/files/ME-PR-TAKUWA-Y-kaken 2012-6p.pdf"},"version_id":"3fa53cb4-b123-4d5f-a65f-a2885c92afd1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"心血管ホメオスターシスとその破綻における機能性脂質の役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"心血管ホメオスターシスとその破綻における機能性脂質の役割"},{"subitem_title":"Role of functional lipids in cardiovascular homeostasis and diseases","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-14"},"publish_date":"2018-05-14","publish_status":"0","recid":"44376","relation_version_is_last":true,"title":["心血管ホメオスターシスとその破綻における機能性脂質の役割"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:28:23.412975+00:00"}