{"created":"2023-07-27T06:51:06.924112+00:00","id":44390,"links":{},"metadata":{"_buckets":{"deposit":"6e82cd9e-1912-472e-ad2c-eb290cb74760"},"_deposit":{"created_by":18,"id":"44390","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44390"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044390","sets":["2812:2813:2817"]},"author_link":["70236","118"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-29","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2014-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、エリスロポエチン(EPO)とその受容体EPORを介する臓器合併症、ことに腎症の機序解明を目指し、糖尿病臓器合併症の共通進展機序である炎症、線維化に着目した。ヒト培養血管内皮細胞を用いて高糖,EPO投与有無による網羅解析とそこから得られる特異的応答分子機構を検討した。新規パスウェイとしてthioredoxin interacting proteinなどインフラマゾーム活性化につながる経路を同定した。一方、EPO投与により炎症、線維化シグナル、サイトカイン発現の低下を確認した。これらより、EPOはその受容体を介して、炎症、線維化カスケードの制御を行い病態に影響を与えている可能性がある。","subitem_description_type":"Abstract"},{"subitem_description":"Diabetic nephropathy is a leading cause of end-stage kidney disease requiring renal replacement therapy in the world. Therefore, it is of importance to examine the pathogenesis of progressive organ involvement in diabetic condition. Thus far, the presence of anemia is an independent risk factor for the progression of diabetic nephropathy. In this study, we focused on the role of erythropoietin (EPO) and its receptor (EPOR), which are closely related to anemia in kidney diseases, especially in the inflammatory processes during the progression of diabetic nephropathy. Endothelial cells express inflammatory and fibrotic mediators through the activation of inflammasome in response to high glucose conditions, which could be modulated by the presence of EPO. These results suggest that EPO-EPOR axis may play a role in the pathogenesis of diabetic nephropathy.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26293127, 研究期間(年度):2014-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「糖尿病臓器合併症の個別化医療にむけた抗エリスロポエチン受容体抗体の基礎臨床的検討」研究成果報告書　課題番号26293127\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26293127/26293127seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050732","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40334784"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40334784","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26293127/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26293127/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26293127/26293127seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26293127/26293127seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-14"}],"displaytype":"detail","filename":"ME-PR-WADA-T-kaken 2017-6p.pdf","filesize":[{"value":"185.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-WADA-T-kaken 2017-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44390/files/ME-PR-WADA-T-kaken 2017-6p.pdf"},"version_id":"ab514334-294a-4f61-b02d-9b1e42f82d18"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"糖尿病臓器合併症の個別化医療にむけた抗エリスロポエチン受容体抗体の基礎臨床的検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"糖尿病臓器合併症の個別化医療にむけた抗エリスロポエチン受容体抗体の基礎臨床的検討"},{"subitem_title":"Association of anti-erythropoietin receptor antibodies with organ involvement of diabetic complications","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-14"},"publish_date":"2018-05-14","publish_status":"0","recid":"44390","relation_version_is_last":true,"title":["糖尿病臓器合併症の個別化医療にむけた抗エリスロポエチン受容体抗体の基礎臨床的検討"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:36:13.696047+00:00"}