{"created":"2023-07-27T06:51:07.058196+00:00","id":44393,"links":{},"metadata":{"_buckets":{"deposit":"a95709b3-9a6a-49fa-8f78-6f06a238e531"},"_deposit":{"created_by":18,"id":"44393","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44393"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044393","sets":["2812:2813:2823"]},"author_link":["70236","118"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-04-25","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2008-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"CD45/I型コラーゲン二重陽性細胞に着目し、腎間質線維化ならびに心線維化を中心とした心腎連関への関与を検討した。この線維化を基盤とする心腎連関モデルの作成により、CD45/I型コラーゲン二重陽性細胞の心ならびに腎の線維化への関与が示唆された。また、臨床的に線維化を反映する臨床検査診断法の確立への期待は強い。今回、CD45/I型コラーゲン二重陽性細胞の測定系が樹立され、今後、臨床上の有用性を検討していきたい。","subitem_description_type":"Abstract"},{"subitem_description":"CD45^<+/>Collagen I^+ dual positive cells migrate into fibrotic kidney dependent on chemokine system, which may promote and escalate chronic inflammatory processes and possible interaction with resident stromal cells, thereby perpetuating renal fibrosis. In addition, our present data suggest the possible involvement of CD45^+/Collagen I^+ dual positive cells in cardiac fibrosis, closely related to renal lesions. Furthermore, the detection of CD45^+/Collagen I^+ dual positive cells in circulation has been established in this study.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典:研究課題「心腎連関機序: 新規骨髄由来細胞の関与とその臨床評価システムの構築」課題番号20590952\n(KAKEN:科学研究費助成事業データベース(国立情報学研究所)) \n(https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20590952/20590952seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050735","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40334784"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40334784","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590952/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590952/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20590952/20590952seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20590952/20590952seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-14"}],"displaytype":"detail","filename":"ME-PR-WADA-T-kaken 2011-6p.pdf","filesize":[{"value":"206.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-WADA-T-kaken 2011-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44393/files/ME-PR-WADA-T-kaken 2011-6p.pdf"},"version_id":"377bc37c-0961-4e83-aaea-1cb46cd24544"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"心腎連関機序: 新規骨髄由来細胞の関与とその臨床評価システムの構築","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"心腎連関機序: 新規骨髄由来細胞の関与とその臨床評価システムの構築"},{"subitem_title":"Possible involvement of CD45+/collagen I+ dual positive cells in renal fibrosis and cardiorenal syndrome","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-14"},"publish_date":"2018-05-14","publish_status":"0","recid":"44393","relation_version_is_last":true,"title":["心腎連関機序: 新規骨髄由来細胞の関与とその臨床評価システムの構築"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:17:54.120768+00:00"}