{"created":"2023-07-27T06:51:07.469300+00:00","id":44404,"links":{},"metadata":{"_buckets":{"deposit":"b0589123-1b37-4fd5-a4d2-c4daf10eaf81"},"_deposit":{"created_by":18,"id":"44404","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44404"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044404","sets":["2812:2813:2816"]},"author_link":["50593","324"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-18","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2015-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"タンパク質主体の魚類がでんぷん給餌で高血糖が続く特徴を利用し、高でんぷん食で長時間高血糖が続く新規2 型糖尿病キンギョモデルを作製した。本モデルでは、ウロコI型コラーゲン線維糖化に伴う線維間架橋割合が増加していた。また、力学的3点曲げ試験解析から糖化に伴いコラーゲン線維の弾性低下と曲げ強度の有意な低下を示した。以上より、高血糖由来の骨の主構造タンパクの糖化で骨の易骨折性が起きる可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"We used fish, characterized by a prolonged hour hyperglycemia after starch-rich feeding, as a unique model of type 2 DM. In this model, the interfibrous crosslinking caused by production of advanced glycation end products accompanying the glycation of type I collagen fiber was increased. Furthermore, analysis of three-points bending test of glycated type I collagen fiber demonstrated that the increment of interfibrous crosslinking of collagen fibers leads to decrease of collagen fiber elasticity and of bending strength of collagen fiber. Our results indicated that the glycation of bone structure proteins bring increment of fracture risk.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K01705, 研究期間(年度):2015-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「新規2型糖尿病骨代謝モデルによる糖尿病骨代謝機構解析と運動による改善法の提案」課題番号15K01705\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K01705/15K01705seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域保健学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050746","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80283117"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80283117","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K01705/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K01705/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K01705/15K01705seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K01705/15K01705seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-12"}],"displaytype":"detail","filename":"ME-PR-KITAMURA-K-kaken 2018-4p.pdf","filesize":[{"value":"106.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KITAMURA-K-kaken 2018-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44404/files/ME-PR-KITAMURA-K-kaken 2018-4p.pdf"},"version_id":"2e4757d5-640f-4f5a-9222-a8abef2e4c0e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"新規2型糖尿病骨代謝モデルによる糖尿病骨代謝機構解析と運動による改善法の提案","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規2型糖尿病骨代謝モデルによる糖尿病骨代謝機構解析と運動による改善法の提案"},{"subitem_title":"Analysis of bone metabolism under hyperglycemia using unique type 2 diabetes model and proposal of improvement method for bone metabolism in type 2 diabetes by exercise","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-12"},"publish_date":"2019-04-12","publish_status":"0","recid":"44404","relation_version_is_last":true,"title":["新規2型糖尿病骨代謝モデルによる糖尿病骨代謝機構解析と運動による改善法の提案"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:03:12.454021+00:00"}