{"created":"2023-07-27T06:51:09.971371+00:00","id":44461,"links":{},"metadata":{"_buckets":{"deposit":"37da3965-f0ad-439b-b921-14486d0d49e1"},"_deposit":{"created_by":18,"id":"44461","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44461"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044461","sets":["2812:2813:2817"]},"author_link":["76139","2575"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-18","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2015-04-01 - 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"多発性硬化症は自己免疫が関与する中枢神経系の脱髄疾患であるが、中枢神経系の細胞の病態への関与については未だ不明な点が多い。本研究では中枢神経系においてアストロサイト特異的に発現する分子Ndrg2に注目し、同分子を介したアストロサイトの多発性硬化症病態への関与と、その分子メカニズムの解明を行った。その結果、アストロサイトNdrg2は運動ニューロンのダメージを調節することで麻痺症状に関与し、多発性硬化症の病態形成に寄与することが明らかとなった。","subitem_description_type":"Abstract"},{"subitem_description":"Multiple sclerosis (MS) is autoimmune disease of the central nervous system (CNS), however, the involvement of the CNS parenchymal cells to the pathology is not fully elucidated. N-myc downstream-regulated gene 2 (Ndrg2) is a differentiation-associated molecule predominantly expressed in astrocytes in the central nervous system. In this study, we examined the expression and the role of Ndrg2 in MS pathology, and its underlying mechanisms using a mouse model of MS, experimental autoimmune encephalomyelitis (EAE). The current study demonstrated that Ndrg2 is involved in neurological symptom through the regulation of motor neuron damages during the pathogenesis of EAE.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K18374, 研究期間(年度):2015-04-01 - 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「中枢神経系脱髄疾患におけるアストロサイト特異的遺伝子Ndrg2の重要性」研究成果報告書　課題番号15K18374\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K18374/15K18374seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系 ","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050803","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=40565412"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40565412","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K18374/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K18374/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K18374/15K18374seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K18374/15K18374seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-21"}],"displaytype":"detail","filename":"ME-PR-TAKARADA-M-kaken 2017-4p.pdf","filesize":[{"value":"191.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-TAKARADA-M-kaken 2017-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44461/files/ME-PR-TAKARADA-M-kaken 2017-4p.pdf"},"version_id":"ce322759-85f8-4253-ae78-cbf179f566b6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"中枢神経系脱髄疾患におけるアストロサイト特異的遺伝子Ndrg2の重要性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"中枢神経系脱髄疾患におけるアストロサイト特異的遺伝子Ndrg2の重要性"},{"subitem_title":"The role of Ndrg2 in multiple sclerosis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-21"},"publish_date":"2018-05-21","publish_status":"0","recid":"44461","relation_version_is_last":true,"title":["中枢神経系脱髄疾患におけるアストロサイト特異的遺伝子Ndrg2の重要性"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:36:09.452865+00:00"}