{"created":"2023-07-27T06:51:10.060041+00:00","id":44464,"links":{},"metadata":{"_buckets":{"deposit":"447eb474-2c19-4ce9-bcb9-efb248170685"},"_deposit":{"created_by":18,"id":"44464","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44464"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044464","sets":["2812:2813:2816"]},"author_link":["24022","512"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-06-01","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2015-04-01 - 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"脳の中には,神経細胞と共に脳を構成するグリア細胞が存在し，その数は脳の細胞の50％以上を占めると言われています。このグリア細胞が脳の働きにとって重要であることが最近注目されはじめています。我々は、自閉症に関連がある遺伝子「CD38」の異常によりアストロサイトとオリゴデンドロサイトというグリア細胞に発達の遅れが起こることを見いだしました。CD38遺伝子の欠損したマウスは社会性の異常を示すことから、その一因としてグリア細胞の発達異常が考えられます。本研究を発展させることにより，自閉症をはじめとした脳の発達障害の原因究明，診断・治療法の開発につながることが期待されます。","subitem_description_type":"Abstract"},{"subitem_description":"The brain consists of neurons and glial cells. Recent research uncovers the importance of glial cells; their developmental abnormality causes various diseases such as autism spectrum disorders and aberrant cerebral cortex development. Herein, CD38 gene knocking-out is shown to cause aberrant development of glial cells, especially, those called astrocytes and oligodendrocytes. As CD38 knockout mouse exhibits abnormal social behavior, these abnormal glial development may be one of the reason for the abnormal behavior. The present study suggests the importance of glial cells for the cerebral cortex development and social behavior.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K06753, 研究期間(年度):2015-04-01 - 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「オリゴデンドロサイト発達異常に着目した自閉症モデル動物の解析」課題番号15K06753\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K06753/15K06753seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050806","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50457024"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50457024","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K06753/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K06753/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K06753/15K06753seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K06753/15K06753seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-12"}],"displaytype":"detail","filename":"ME-PR-HATTORI-T-kaken 2018-4p.pdf","filesize":[{"value":"81.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-HATTORI-T-kaken 2018-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44464/files/ME-PR-HATTORI-T-kaken 2018-4p.pdf"},"version_id":"36fd2790-1fc0-4cb3-a3a2-80896646c7b3"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"オリゴデンドロサイト発達異常に着目した自閉症モデル動物の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"オリゴデンドロサイト発達異常に着目した自閉症モデル動物の解析"},{"subitem_title":"Analysis of development of oligodendtocytes in autism-related mouse model","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-12"},"publish_date":"2019-04-12","publish_status":"0","recid":"44464","relation_version_is_last":true,"title":["オリゴデンドロサイト発達異常に着目した自閉症モデル動物の解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:01:30.006901+00:00"}