{"created":"2023-07-27T06:51:10.104465+00:00","id":44465,"links":{},"metadata":{"_buckets":{"deposit":"08cf0bc7-f15b-4e3f-a070-fdf724cc9e60"},"_deposit":{"created_by":18,"id":"44465","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"44465"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00044465","sets":["2812:2813:2821"]},"author_link":["24022","512"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2011-2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hattori, Tsuyoshi"}],"nameIdentifiers":[{"nameIdentifier":"24022","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50457024","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50457024"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究で、精神疾患のリスク遺伝子”DISC1”が神経細胞だけでなくオリゴデンドロサイトにも発現し、DISC1が転写因子であるSox10やNkx2.2発現量を抑制することによりオリゴデンドロサイトの発達を制御していることを発見した。また、DISC1の結合因子であるDBZもオリゴデンドロサイトの発達を制御することがわかった。これらの結果より、オリゴデンドロサイトの発達異常が精神疾患発症のリスクを高めている可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"In this study, we found that DISC1, a kind of gene related with mental illness, regulates development of oligodendrocytes by controlling expression level of Sox10 and Nkx2.2. Furthermore, we found that DBZ, a binding-partner of DISC1, also regulates development of oligodendrocytes in vitro and in vivo. These results suggest that abnormal development of oligodendrocytes may be involved in mechanisms of developing mental illness.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23700415, 研究期間(年度):2011-2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「精神疾患リスク遺伝子のオリゴデンドロサイトにおける機能解析」課題番号23700415\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23700415/23700415seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050807","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50457024"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50457024","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23700415/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23700415/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23700415/23700415seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23700415/23700415seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"服部, 剛志"}],"nameIdentifiers":[{"nameIdentifier":"512","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50457024","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50457024"},{"nameIdentifier":"50457024","nameIdentifierScheme":"金沢大学研究者情報","nameIdentifierURI":"http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=50457024"},{"nameIdentifier":"50457024","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000050457024"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-21"}],"displaytype":"detail","filename":"ME-PR-HATTORI-T-kaken 2014-4p.pdf","filesize":[{"value":"122.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-HATTORI-T-kaken 2014-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/44465/files/ME-PR-HATTORI-T-kaken 2014-4p.pdf"},"version_id":"891128b8-16b2-45c1-8fde-e0e2f589a5b8"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"精神疾患リスク遺伝子のオリゴデンドロサイトにおける機能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"精神疾患リスク遺伝子のオリゴデンドロサイトにおける機能解析"},{"subitem_title":"Functional analysis of mental illness related genes in oligodendrocytes","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-21"},"publish_date":"2018-05-21","publish_status":"0","recid":"44465","relation_version_is_last":true,"title":["精神疾患リスク遺伝子のオリゴデンドロサイトにおける機能解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:54:07.493870+00:00"}